Factors associated with mortality in hospitalized patients with newly diagnosed tuberculosis.

Lung
Denise Rossato SilvaPaulo de Tarso Roth Dalcin

Abstract

The purpose of this study was to identify clinical and epidemiological factors associated with death in patients with an in-hospital diagnosis of tuberculosis (TB), in a city with a high prevalence of TB and human immunodeficiency virus (HIV) infection. The study was a retrospective, cohort study conducted at a general, tertiary-care, university-affiliated hospital. Patients who began treatment for TB after hospitalization were included. Predictors of mortality were assessed. The primary outcomes were the in-hospital mortality and the mortality after discharge. We evaluated the medical records of 311 patients with TB. The overall mortality rate of all study participants was 99/311 (31.8%). The mortality rates during hospitalization and after discharge were 50/311 (16.1%) and 49/261 (18.8%), respectively. Mechanical ventilation, consolidation in chest X-ray, and negative sputum smear were predictors of in-hospital death in multivariate analysis. Independent predictors of mortality after discharge in multivariate analysis included total duration of hospitalization and being a current smoker. We found a high overall mortality rate for patients hospitalized with TB in a region with a high prevalence of TB and HIV. The risk of morta...Continue Reading

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Citations

Jan 29, 2013·Annals of Biomedical Engineering·Vinayak SwarnkarRina Triasih
Sep 17, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·Nicole T BurtonAwewura Kwara
Mar 6, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Yung-Feng YenChung-Yeh Deng
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May 10, 2018·Scientific Reports·Carlos Podalirio Borges de AlmeidaDenise Rossato Silva
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