Factors Associated With Mortality in Pediatric vs Adult Nasopharyngeal Carcinoma

JAMA Otolaryngology-- Head & Neck Surgery
Morgan K RichardsSanjay R Parikh

Abstract

Nasopharyngeal carcinoma (NPC) is endemic in some Asian regions but is uncommon in the United States. Little is known about the racial, demographic, and biological characteristics of the disease in pediatric patients. To improve understanding of the differences between pediatric and adult NPC and to determine whether race conferred a survival difference among pediatric patients with NPC. This retrospective cohort study included all 17 317 patients with a primary diagnosis of NCP in the National Cancer Data Base from January 1, 1998, to December 31, 2011. Of these, 699 patients were 21 years or younger (pediatric); 16 618 patients, older than 21 years (adult). Data were analyzed after data collection. Pediatric age at diagnosis of NPC. Demographic, tumor, and treatment characteristics of pediatric patients with NPC were compared with those of adults using the χ2 test for categorical variables. An adjusted Cox proportional hazards regression model was used to examine survival differences in pediatric patients relative to adult patients. In addition, the risk for pediatric mortality by race was estimated. Of the 17 317 patients, a total of 699 pediatric and 16 618 adult patients were identified with a primary diagnosis of NPC (fem...Continue Reading

Citations

Sep 15, 2018·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Sai D ChallapalliNosayaba Osazuwa-Peters
Jul 16, 2019·Clinical Obstetrics and Gynecology·Ama Bus-KwofieKevin Holcomb
Aug 31, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Gunes OrmanThierry A G M Huisman
Jan 7, 2017·Annals of Surgical Oncology·Morgan K RichardsSara H Javid
Sep 17, 2019·Pediatric Blood & Cancer·Haruka UezonoJulie A Bradley
Jul 14, 2020·International Journal of Pediatric Otorhinolaryngology·Mehdi HasnaouiNabil Driss

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