Factors associated with nocturnal hypoglycemia in at-risk adolescents and young adults with type 1 diabetes

Diabetes Technology & Therapeutics
Darrell M WilsonIn Home Closed Loop Study Group

Abstract

Hypoglycemia remains an impediment to good glycemic control, with nocturnal hypoglycemia being particularly dangerous. Information on major contributors to nocturnal hypoglycemia remains critical for understanding and mitigating risk. Continuous glucose monitoring (CGM) data for 855 nights were studied, generated by 45 subjects 15-45 years of age with hemoglobin A1c (HbA1c) levels of ≤8.0% who participated in a larger randomized study. Factors assessed for potential association with nocturnal hypoglycemia (CGM measurement of <60 mg/dL for ≥30 min) included bedtime blood glucose (BG), exercise intensity, bedtime snack, insulin on board, day of the week, previous daytime hypoglycemia, age, gender, HbA1c level, diabetes duration, daily basal insulin, and daily insulin dose. Hypoglycemia occurred during 221 of 885 (25%) nights and was more frequent with younger age (P<0.001), lower HbA1c levels (P=0.006), medium/high-intensity exercise during the preceding day (P=0.003), and the occurrence of antecedent daytime hypoglycemia (P=0.001). There was a trend for lower bedtime BG levels to be associated with more frequent nocturnal hypoglycemia (P=0.10). Bedtime snack, before bedtime insulin bolus, weekend versus weekday, gender, and dail...Continue Reading

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
May 22, 2002·JAMA : the Journal of the American Medical Association·Arleta RewersGeorgeanna Klingensmith
Nov 1, 2002·The Journal of Pediatrics·Francine Ratner KaufmanPisit Pitukcheewanont
Oct 18, 2005·The Journal of Pediatrics·Eva TsalikianUNKNOWN Diabetes Research In Children Network Direcnet Study Group
Aug 13, 2008·Diabetes Care·Bruce BuckinghamFergus Cameron
Oct 17, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Robert J TanenbergAlmond J Drake
Mar 5, 2010·Diabetes Care·UNKNOWN Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
Jun 16, 2012·Diabetes Care·Rozalina G McCoySteven A Smith
Jul 25, 2012·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Meryl BrodTorsten Christensen
Jun 14, 2013·The Journal of Clinical Endocrinology and Metabolism·Ruth S WeinstockUNKNOWN T1D Exchange Clinic Network
Jan 11, 2014·Diabetes Technology & Therapeutics·Satish K GargFrancine R Kaufman
May 9, 2014·Diabetes Care·David M MaahsUNKNOWN In Home Closed Loop Study Group

❮ Previous
Next ❯

Citations

May 10, 2016·Diabetes Technology & Therapeutics·H Peter Chase
May 24, 2016·Canadian Journal of Diabetes·Jordan E PinskerDavid Kerr
Jun 18, 2016·Journal of Diabetes and Its Complications·Andreas HolsteinJudith D Holstein
Dec 4, 2015·Journal of Diabetes Science and Technology·Katharine BarnardGeorge Serbedzija
May 20, 2015·Journal of Diabetes Science and Technology·Ram WeissUNKNOWN ASPIRE In-Home Study Group
Jul 19, 2017·Diabetes, Obesity & Metabolism·Ravi ReddyPeter G Jacobs
Jun 28, 2019·The Diabetes Educator·Alissa J RobertsCraig E Taplin
Apr 17, 2020·Diabetes Technology & Therapeutics·Clara Mosquera-LopezPeter G Jacobs
Aug 16, 2016·Current Diabetes Reports·Dayna E McGill, Lynne L Levitsky
Nov 3, 2016·Journal of Diabetes Science and Technology·Peter M CalhounUNKNOWN In Home Closed Loop Study Group

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01591681

Software Mentioned

SAS

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.