Factors associated with plasma antigen carbohydrate 125 and amino-terminal pro-B-type natriuretic peptide concentrations in acute heart failure.

European Heart Journal. Acute Cardiovascular Care
Gema MiñanaJulio Núñez

Abstract

Plasma amino-terminal pro-B-type natriuretic peptide and antigen carbohydrate 125 levels are positively associated with a higher risk of adverse clinical outcomes in acute heart failure. As a proxy of congestion, antigen carbohydrate 125 has also been proposed as a right-sided heart failure marker. Thus, we aimed to determine in this population the main factors - including echocardiographic right-sided heart failure parameters - associated with antigen carbohydrate 125 and amino-terminal pro-B-type natriuretic peptide. We prospectively included 2949 patients admitted with acute heart failure. Amino-terminal pro-B-type natriuretic peptide and antigen carbohydrate 125 were used as dependent variables in a multivariable linear regression analysis. The mean age of the sample was 73.9±11.1 years; 48.9% were female, 35.8% showed ischaemic aetiology, and 51.6% exhibited heart failure with preserved ejection fraction. The median (interquartile range) for amino-terminal pro-B-type natriuretic peptide and antigen carbohydrate 125 were 4840 (2111-9204) pg/ml and 58 (26-129) U/ml, respectively. In a multivariable setting, and ranked in order of importance (R2), estimated glomerular filtration rate (43.7%), left ventricle ejection fraction ...Continue Reading

References

May 29, 2007·European Journal of Heart Failure·Jochem HogenhuisDirk J van Veldhuisen
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Aug 9, 2013·Heart Failure Reviews·Julio NúñezJuan Sanchis
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Aug 20, 2019·The American Journal of Medicine·Julio NúñezAntoni Bayés-Genís

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Citations

Jul 15, 2020·European Heart Journal. Acute Cardiovascular Care·Frederik H Verbrugge
Apr 9, 2021·European Heart Journal. Acute Cardiovascular Care·Gonzalo Núñez-MarínJulio Núñez
Apr 20, 2021·Medical Hypotheses·Esra Dökümcü
Jul 10, 2021·European Journal of Heart Failure·Julio NúñezAntoni Bayés-Genís
Sep 12, 2021·European Journal of Internal Medicine·Rafael de la EspriellaJulio Núñez

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