Factors Associated with Positive Adenosine Challenge Test in Young Children with Suspected Asthma

Pediatric Allergy, Immunology, and Pulmonology
Gabriel LevinAmihai Rottensctreich

Abstract

Background: To investigate the predictive factors associated with positive adenosine monophosphate challenge using the auscultation method (AMP-PCW) test results. Methods: This is a prospective study of young children with suspected asthma who underwent AMP-PCW test. Patients with a positive AMP-PCW test were compared with those with a negative AMP-PCW. A multivariate logistic regression model was performed to identify the independent determinants of positive AMP-PCW. Results: A total of 159 patients completed the AMP-PCW test. The median age was 53 months. In total, 54.0% of patients had a positive AMP-PCW. The prevalence of atopic dermatitis and family history of asthma and allergy were significantly higher among the positive AMP-PCW group (P = 0.04, P = 0.02, and P = 0.007, respectively), as were the prevalences of elevated immunoglobulin E (IgE), peripheral blood eosinophils percentage (P = 0.003, P < 0.001, respectively), and number of emergency department (ED) visits/hospitalizations before AMP-PCW test (P = 0.006). A significant inverse correlation exists between peripheral blood eosinophils percentage and serum IgE levels with the AMP end-point concentrations (r = -0.302, P = 0.001, and r = -0.312, P = 0.001, respe...Continue Reading

References

Aug 1, 1991·Archives of Disease in Childhood·N NoviskiS Godfrey
May 1, 1991·The American Review of Respiratory Disease·A G DriverS J Mustafa
Jan 1, 1989·The American Review of Respiratory Disease·P N LesouëfL I Landau
Feb 1, 1985·The Journal of Allergy and Clinical Immunology·M J Cushley, S T Holgate
Apr 1, 1988·The Journal of Pediatrics·A AvitalS Godfrey
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·C SpringerA Avital
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·M Van Den BergeD S Postma
Jan 31, 2002·American Journal of Respiratory and Critical Care Medicine·Gea De MeerDirkje S Postma
Feb 18, 2004·Pediatric Pulmonology·Simon GodfreyAvraham Avital
Dec 15, 2004·British Journal of Clinical Pharmacology·M J CushleyS T Holgate
Jan 26, 2005·Pediatric Pulmonology·Simon GodfreyChaim Springer
Aug 24, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Arzu Bakirtas, Ipek Turktas
Jan 11, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D K KimY Y Koh
Jan 28, 2009·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Simon Godfrey
Apr 21, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Luis MansoJoaquín Sastre
Nov 2, 2012·Allergy, Asthma & Immunology Research·Sung Han KangSoo-Jong Hong
Jan 22, 2013·Nature Reviews. Drug Discovery·Patricia C Fulkerson, Marc E Rothenberg
Jul 3, 2016·Wiener klinische Wochenschrift·Fritz HorakMichael Studnicka
Nov 22, 2016·Primary Care·Anna Kovalszki, Peter F Weller
Jan 15, 2018·Pulmonary Pharmacology & Therapeutics·Anne J LexmondMaarten van den Berge

❮ Previous
Next ❯

Software Mentioned

PCW
AMP

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.