Factors associated with positive D-dimer results in patients evaluated for pulmonary embolism.

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
Christopher KabrhelJeffrey A Kline

Abstract

Available D-dimer assays have low specificity and may increase radiographic testing for pulmonary embolism (PE). To help clinicians better target testing, this study sought to quantify the effect of risk factors for a positive quantitative D-dimer in patients evaluated for PE. This was a prospective, multicenter, observational study. Emergency department (ED) patients evaluated for PE with a quantitative D-dimer were eligible for inclusion. The main outcome of interest was a positive D-dimer. Odds ratio (ORs) and 95% confidence intervals (CIs) were determined by multivariable logistic regression. Adjusted estimates of relative risk were also calculated. A total of 4,346 patients had D-dimer testing, of whom 2,930 (67%) were women. A total of 2,500 (57%) were white, 1,474 (34%) were black or African American, 238 (6%) were Hispanic, and 144 (3%) were of other race or ethnicity. The mean (+/-SD) age was 48 (+/-17) years. Overall, 1,903 (44%) D-dimers were positive. Model fit was adequate (c-statistic = 0.739, Hosmer and Lemeshow p-value = 0.13). Significant positive predictors of D-dimer positive included female sex; increasing age; black (vs. white) race; cocaine use; general, limb, or neurologic immobility; hemoptysis; hemodial...Continue Reading

References

Jun 1, 1983·The American Journal of Medicine·S Z GoldhaberM Feinleib
Feb 26, 1997·JAMA : the Journal of the American Medical Association·S Z GoldhaberC H Hennekens
Jan 1, 1997·International Journal of Clinical & Laboratory Research·I FrancalanciR Abbate
Dec 1, 1998·JAMA : the Journal of the American Medical Association·J Zhang, K F Yu
Oct 6, 2000·The American Journal of Medicine·M RighiniA Perrier
Apr 21, 2004·Annals of Internal Medicine·Paul D SteinNeeraj K Kalra
Jan 27, 2005·Journal of Thrombosis and Haemostasis : JTH·M EpineyP De Moerloose
Feb 11, 2005·JAMA : the Journal of the American Medical Association·Jean-Noel FiessingerUNKNOWN THRIVE Treatment Study Investigators
Mar 15, 2005·Clinical Chemistry·Jeffrey A KlineJackeline Hernandez-Nino
Sep 17, 2005·The American Journal of Medicine·Paul D SteinRonald E Olson
Feb 24, 2006·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Peter B RichmanJeffrey A Kline
Mar 23, 2006·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Christopher KabrhelThomas Ptak
Apr 1, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mohammed T AnsariJohan Pe Karlberg
Apr 8, 2006·Thrombosis and Haemostasis·Marc RighiniArnaud Perrier
May 19, 2006·Journal of Thrombosis and Haemostasis : JTH·M CanonicoUNKNOWN EStrogen and THromboEmbolism Risk (ESTHER) Study Group
Jun 22, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mohammed T AnsariJohan P E Karlberg
Jun 29, 2007·Journal of Thrombosis and Haemostasis : JTH·M RighiniA Perrier
Mar 6, 2008·Journal of Thrombosis and Haemostasis : JTH·J A KlineK Nordenholz
Oct 10, 2008·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tomonori MisakiKatsuro Tomita
Jan 13, 2009·Annals of Emergency Medicine·Daren M BeamJeffrey A Kline
Apr 18, 2009·Obesity·Christopher KabrhelCarlos A Camargo

❮ Previous
Next ❯

Citations

Feb 26, 2013·Journal of Thrombosis and Thrombolysis·Rakhi P NaikSophie Lanzkron
Aug 3, 2011·Irish Journal of Medical Science·H ChenJ Zhang
Oct 20, 2011·Advances in Therapy·Theodoros MoysidisKnut Kröger
Aug 13, 2011·American Journal of Respiratory and Critical Care Medicine·Armand Mekontso DessapBernard Maitre
Mar 15, 2014·PloS One·Alvaro H BorgesUNKNOWN SILCAAT Scientific Committee
Jan 16, 2016·Thrombosis Journal·Gerhardus J A J M KuiperYvonne M C Henskens
Sep 19, 2012·Journal of Clinical Anesthesia·Grace C McCarthyAshraf S Habib
Sep 12, 2015·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Felix Samuel ShonyelaJia Jiao
May 10, 2012·Journal of Thrombosis and Haemostasis : JTH·A PenalozaF Thys
Jul 12, 2013·Internal Medicine Journal·I T LingG F Ryan
Oct 2, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Christopher R Carpenter, Ali S Raja
Jul 14, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Scott T Wilber, Rongwei Fu
Dec 2, 2015·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Zhou YinZhexin Shao
Apr 6, 2016·The American Journal of Medicine·Eyal FuchsInna Tzoran
Nov 26, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·John V AshurstChristopher L Moore
Mar 25, 2015·The Journal of Emergency Medicine·Jeffrey A Kline, Christopher Kabrhel
Nov 6, 2014·International Journal of Legal Medicine·Hannah HoltkötterMarielle Vennemann
Feb 3, 2016·Chest·Alem Mehari, Elizabeth S Klings
Jun 8, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Paul D SteinJoseph Tworek
Jan 21, 2020·Circulation. Cardiovascular Quality and Outcomes·Jeffrey A KlineD Mark Courtney
Jan 9, 2020·Critical Care Medicine·Joerg C SchefoldCarmen A Pfortmueller
Sep 8, 2020·Epidemiology and Infection·Daniel Martin Simadibrata, Anna Mira Lubis
Mar 20, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Chong ChenYa-Jun Gu
Dec 18, 2014·The Nurse Practitioner·Jennifer Wilbeck, Dian Evans
Feb 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Victoria L Stefanelli, Thomas H Barker
Feb 13, 2020·F1000Research·Ella Ishaaya, Victor F Tapson
Aug 26, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Jeffrey S BergerLeora I Horwitz
Jun 19, 2017·European Journal of Medical Research·Katongo MutengoOwen Ngalamika
Oct 13, 2016·Current Cardiology Reports·Matthew J FeinsteinChristopher T Longenecker
Jul 16, 2020·BMC Infectious Diseases·Chloe A TeasdaleWafaa M El-Sadr
Mar 25, 2020·Critical Care Medicine·Joerg C SchefoldCarmen A Pfortmueller
Aug 23, 2017·Case Reports in Cardiology·Jonathan M YaghoubianUri M Ben-Zur
Dec 7, 2019·Therapeutic Advances in Drug Safety·Elise CarpenterJohn Gums

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