Factors associated with primary and secondary graft failure following cadaveric kidney transplant

Clinical Transplantation
Inbal Weiss-SalzIsraeli Transplantation Consortium

Abstract

The risk profile for primary renal graft failure is largely unknown because of its inclusion with secondary failures or its exclusion from analysis. This study compares characteristics of the cadaveric transplant recipients who experienced primary failure, secondary failures or survived with a functioning graft for at least 6 months. Medical records of all cadaveric kidney-transplant patients performed in Israel over a 3-yr period 1997-2000 were reviewed. Fisher's exact test and multinomial regression models were used to assess the association of demographic, pre-operative and operative risk factors with the two types of failure outcomes. Of 325 grafts, 54 (16.6%) failed of which half were primary failures. Univariate analysis demonstrated a significant trend of increasing proportion of patients with specific risk factors from the functioning grafts group to the secondary and to the primary graft failure groups. Independent risk factors for primary graft failure included 'surgical complications', 'donor's age > or =60 yr', 'waiting for transplant > or =6 yr', and 'human leukocyte antigen-DR (HLA-DR) mismatch', based on the multivariate model. These factors may reflect the scarcity of organ donations in Israel, which leads to a ...Continue Reading

References

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Citations

Jun 11, 2010·Transplantation Proceedings·N Guimarães-SouzaM Cendoroglo
Jun 13, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J F JohnsonA A House
Nov 9, 2007·Clinical Transplantation·Helena Moisés MendonçaAlvaro Pacheco-Silva
Jan 3, 2006·Transplantation Proceedings·D Truan CachoR Gutiérrez del Pozo
Jun 1, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David W JohnsonDavid L Nicol
Dec 31, 2020·International Journal of Molecular Sciences·Arnau Panisello-RosellóRené Adam

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