Abstract
To identify, characterize, and quantify associations of various factors with quality of life (QoL) in patients with asthma, according to the pharmacotherapy employed. This was a cross-sectional study involving 49 patients (≥ 18 years of age) with severe uncontrolled or refractory asthma treated at a specialized outpatient clinic of the Brazilian Unified Health Care System, regularly using high doses of inhaled corticosteroids (ICs) or other medications, and presenting comorbidities. At a single time point, QoL was assessed with the Asthma Quality of Life Questionnaire (AQLQ). The overall AQLQ score and those of its domains were correlated with demographic variables (gender and age); Asthma Control Questionnaire score; pharmacotherapy (initial IC dose, inhaler devices, and polytherapy); and comorbidities. Better AQLQ scores were associated with asthma control--overall (OR = 0.38; 95% CI: 0.004-0.341; p < 0.001), "symptoms" domain (OR = 0.086; 95% CI: 0.016-0.476; p = 0.001), and "emotional function" domain (OR = 0.086; 95% CI: 0.016-0.476; p = 0.001)-and with IC dose ≤ 800 µg--"activity limitation" domain (OR = 0.249; 95% CI: 0.070-0.885; p = 0.029). Worse AQLQ scores were associated with polytherapy--"activity limitation" domai...Continue Reading
References
Apr 1, 1993·The American Review of Respiratory Disease·E F JuniperL E Griffith
Apr 2, 1998·BMJ : British Medical Journal·G H GuyattR S Goldstein
May 20, 1999·Chest·E F JuniperD R King
Nov 26, 1999·The European Respiratory Journal·E F JuniperD R King
Oct 3, 2002·The European Respiratory Journal·E D BatemanG L Braunstein
Nov 11, 2003·Critical Reviews in Oncology/hematology·Jeffrey C Delafuente
Feb 26, 2004·The European Respiratory Journal·E F JuniperP M O'Byrne
Aug 16, 2005·Journal of Korean Medical Science·Jae-Sung ChoiChoon-Sik Park
Oct 18, 2005·Respiratory Medicine·Elizabeth F JuniperUNKNOWN GOAL Committee
Oct 3, 2006·Journal of Tropical Pediatrics·D SoléC K Naspitz
Oct 13, 2006·Chest·Kim L LavoieManon Labrecque
Aug 7, 2009·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Isobel T M HeyworthTimothy L Frank
Jan 8, 2010·Revista portuguesa de pneumologia·Lara Noronha FerreiraPedro Lopes Ferreira
Apr 27, 2010·The Oncologist·Ronald J MaggioreArti Hurria
Dec 24, 2010·The European Respiratory Journal·M CazzolaP Rogliani
Feb 19, 2011·Advances in Therapy·M SmallS Fermer
May 16, 2012·PloS One·Andrea S GershonTeresa To
Jun 26, 2012·Respiratory Research·José María OlaguibelUNKNOWN MAGIC Study Group