Factors Associated with Reinitiation of Statin Treatment in Older Patients with Peripheral Arterial Disease

Drugs & Aging
Martin WawruchEmma Aarnio

Abstract

Long-term persistence represents a basic precondition of successful statin treatment in patients with peripheral arterial disease (PAD). The aims of our study were evaluation of reinitiation in older PAD patients who were non-persistent with statin treatment, and identification of patient-related characteristics associated with the patient's probability of reinitiation. Our study cohort included 2977 older patients (≥ 65 years) who were non-persistent with statin treatment in whom PAD was newly diagnosed in 2012. Reinitiation was defined as the first statin prescription recorded after discontinuation. To analyze factors associated with the patient´s probability of reinitiation, Cox regression with time-dependent covariates was applied. After post-discontinuation follow-up of a mean of 27 months, reinitiation of statin treatment was recorded for 1244 (41.8%) patients. Increasing age, Parkinson's disease, being a new statin user (patient in whom statin treatment was initiated in association with PAD diagnosis), general practitioner as the index prescriber who prescribed a statin for the first time after diagnosis of PAD, coadministration of loop diuretics, and longer persistence before discontinuation decreased the patient's like...Continue Reading

References

May 24, 2001·The New England Journal of Medicine·W R Hiatt
Mar 17, 2011·European Journal of Clinical Pharmacology·Maarit Jaana KorhonenRisto Huupponen
Apr 5, 2011·The American Journal of Geriatric Pharmacotherapy·Walid F GelladZachary A Marcum
Apr 11, 2012·British Journal of Clinical Pharmacology·Bernard VrijensUNKNOWN ABC Project Team
Jun 5, 2012·The Canadian Journal of Cardiology·Mark Lemstra, David Blackburn
Jun 6, 2016·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Kehinde O ObamiroLuke R E Bereznicki
Oct 13, 2017·Circulation. Cardiovascular Quality and Outcomes·John N BoothEmily B Levitan
Nov 19, 2017·Heart, Lung & Circulation·Sean M Conte, Peter R Vale
May 8, 2018·Mayo Clinic Proceedings·Richard Ofori-AsensoDanny Liew
Jun 28, 2018·Annals of Internal Medicine·Sabina De GeestBernard Vrijens
Nov 24, 2018·Journal of the American College of Cardiology·Richard Ofori-AsensoDanny Liew
Jan 8, 2019·Drugs & Aging·Srikanth YandrapalliWilbert S Aronow
Jun 28, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Gilles MontalescotUNKNOWN AEGEAN Study Investigators

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