Factors Associated with Serum Levels of Carcinoembryonic Antigen in Healthy Non-smokers

Korean journal of family medicine
Jung-Im NoHee-Jeong Choi

Abstract

Carcinoembryonic antigen (CEA), a serological marker of malignant tumors, demonstrates a modest increase under nonmalignant conditions such as aging and smoking. Also, recent study results suggested that serum CEA levels may be related to insulin resistance or low-grade inflammation. The aim of this study was to investigate the factors associated with serum CEA levels in healthy non-smokers. Data was gathered from 21,501 adults aged 20 and over. We excluded 19,081 subjects who had omissions in anthropometric measurements or laboratory tests, or who had previous or current smoking history. The mean CEA level was 1.18 ± 0.85 ng/dL in males and 0.93 ± 0.73 ng/dL in females. After adjustment for age, CEA level was positively correlated with fasting glucose, glycosylated hemoglobin (HbA1C), high density lipoprotein (HDL) cholesterol, estimated glomerular filtration rate in males. In females, CEA level was positively correlated with fasting glucose, HbA1C, HDL cholesterol, aspartate aminotransferase, and high-sensitivity C-reactive protein. In both gender groups, HbA1C had a strong influence on CEA levels when all other variables were included in the regression model (P < 0.05). Within normal range, serum CEA levels were significantl...Continue Reading

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Citations

Feb 24, 2015·Acta Neuropsychiatrica·Ibrahim KaplanLeyla Çolpan
Jun 28, 2017·Journal of Clinical Laboratory Analysis·Yu-Jin KwonYong-Jae Lee
Feb 7, 2014·Korean journal of family medicine·Yong Gyu Park
May 19, 2018·International Journal of Clinical Oncology·Sung Uk LeeJae Hwan Oh
Aug 11, 2020·Journal of the Chinese Medical Association : JCMA·Chih-Sheng HuangShung-Haur Yang
Dec 8, 2020·Frontiers in Oncology·Asadoor Amirkhani NamagerdiAntonio Giordano

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BETA
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