Factors associated with severe human Rift Valley fever in Sangailu, Garissa County, Kenya

PLoS Neglected Tropical Diseases
Angelle Desiree LaBeaudCharles H King

Abstract

Mosquito-borne Rift Valley fever virus (RVFV) causes acute, often severe, disease in livestock and humans. To determine the exposure factors and range of symptoms associated with human RVF, we performed a population-based cross-sectional survey in six villages across a 40 km transect in northeastern Kenya. A systematic survey of the total populations of six Northeastern Kenyan villages was performed. Among 1082 residents tested via anti-RVFV IgG ELISA, seroprevalence was 15% (CI95%, 13-17%). Prevalence did not vary significantly among villages. Subject age was a significant factor, with 31% (154/498) of adults seropositive vs. only 2% of children ≤15 years (12/583). Seroprevalence was higher among men (18%) than women (13%). Factors associated with seropositivity included a history of animal exposure, non-focal fever symptoms, symptoms related to meningoencephalitis, and eye symptoms. Using cluster analysis in RVFV positive participants, a more severe symptom phenotype was empirically defined as having somatic symptoms of acute fever plus eye symptoms, and possibly one or more meningoencephalitic or hemorrhagic symptoms. Associated with this more severe disease phenotype were older age, village, recent illness, and loss of a fa...Continue Reading

References

Jun 1, 1983·Journal of Clinical Microbiology·B NiklassonT P Gargan
Mar 19, 2002·Emerging Infectious Diseases·Christopher W WoodsUNKNOWN World Health Organization Hemorrhagic Fever Task Force
Mar 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William Anninger, Martin Lubow
Feb 5, 2005·Ophthalmology·Ali Al-HazmiNasser Ahmed
Oct 19, 2005·Optometry : Journal of the American Optometric Association·Steven B Koevary
Aug 6, 2008·Emerging Infectious Diseases·A Desiree LaBeaudCharles H King
Aug 28, 2009·International Ophthalmology·Moncef KhairallahVenu Nadella
Mar 9, 2010·The American Journal of Tropical Medicine and Hygiene·Summerpal S KahlonCharles H King
Aug 13, 2010·The American Journal of Tropical Medicine and Hygiene·Robert F BreimanM Kariuki Njenga
Aug 13, 2010·The American Journal of Tropical Medicine and Hygiene·Patrick M NgukuRobert F Breiman
Aug 13, 2010·The American Journal of Tropical Medicine and Hygiene·Amwayi S AnyanguRobert F Breiman
Aug 23, 2011·PLoS Neglected Tropical Diseases·A Desirée LaBeaudCharles H King

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Citations

Mar 21, 2019·PLoS Neglected Tropical Diseases·Elysse N Grossi-SoysterA Desiree LaBeaud
Jul 17, 2019·The Journal of General Virology·Daniel WrightGeorge M Warimwe
Jul 8, 2017·PLoS Neglected Tropical Diseases·Elizabeth Anne Jessie CookEric Maurice Fèvre
Jul 19, 2017·The American Journal of Tropical Medicine and Hygiene·Elysse N Grossi-SoysterA Desiree Labeaud
Jan 19, 2016·Frontiers in Microbiology·Amy L CarolineAmy L Hartman
Jun 6, 2020·Tropical Medicine and Infectious Disease·Elysse N Grossi-Soyster, A Desiree LaBeaud
Mar 9, 2018·Critical Reviews in Microbiology·Yeping SunWenjun Liu
May 4, 2018·PLoS Neglected Tropical Diseases·Luke NyakarahukaTrevor R Shoemaker
Jan 24, 2020·Annals of Clinical Microbiology and Antimicrobials·Emilie JavelleFabrice Simon
Oct 30, 2020·MSphere·Dominique J BarbeauAnita K McElroy
Jun 3, 2021·Pathogens·Melanie RissmannMartin H Groschup

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

Point Pattern Analysis
SAS
Clusterseer
SPSS

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