PMID: 8892493Nov 1, 1996Paper

Factors associated with the CD4+ lymphocyte count at diagnosis of acquired immunodeficiency syndrome. The AIDS IN EUROPE Study Group

Journal of Clinical Epidemiology
A N PhillipsA M Johnson


To assess which factors are associated with the CD4+ lymphocyte count at the time of AIDS diagnosis we studied 3046 patients in the AIDS IN EUROPE study who were diagnosed with AIDS in 1 of 17 European countries between 1979 and 1989 and for whom the CD4 count at AIDS diagnosis was known. Data were extracted retrospectively from patient case notes, using a standardized form. There was a wide range of average CD4+ lymphocyte counts at AID diagnosis, according to which diseases were present at diagnosis. The highest geometric mean CD4+ lymphocyte counts at AIDS diagnosis were associated with the diagnosis of extrapulmonary tuberculosis, Kaposi's sarcoma, and non-Hodgkin's lymphoma while the lowest counts were found when histoplasmosis and cytomegalovirus (CMV) retinitis were present. There were no appreciable differences between CD4+ lymphocyte counts at AIDS in patients according to the three major transmission route categories (sex, age, or region of diagnosis) but there was a marked trend (p < 0.005) toward lower CD4+ lymphocyte counts at AIDS diagnosis in more recent years. These associations remained largely unchanged after adjustment for other factors.


Feb 16, 1991·Lancet·A N PhillipsP B Kernoff
May 23, 1986·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control (CDC)
Dec 23, 1993·The New England Journal of Medicine·D R HooverR A Kaslow
Apr 23, 1994·BMJ : British Medical Journal·J D LundgrenJ O Nielsen
Apr 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F Gordin, H Masur

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Nov 28, 2009·Epidemiology and Infection·J CollazosUNKNOWN Grupo Español para el Estudio Multifactorial de la Adherencia (GEEMA)
Oct 6, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·UNKNOWN Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE Collaboration)

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