Abstract
Circulating active tissue factor (TF) and activated factor XI (FXIa) have been detected in subgroups of acute coronary syndromes (ACSs) and stable angina patients. We sought to evaluate the determinants of active TF and FXIa in stable angina patients. We studied 124 consecutive stable angina patients. Recent ACS, atrial fibrillation, and anticoagulant therapy were the exclusion criteria. Plasma active TF and FXIa were determined by measuring the response to inhibitory antibodies. T helper 1 lymphocyte (Th1) and Th2 responses were assessed in plasma by interleukin (IL)-4, IL-6, IL-8, IL-10, IL-18, interferon-γ, and tumor necrosis factor-α, oxidative stress by 8-isoprostaglandin F(2α) (8-iso-PGF(2α)), and coagulation by prothrombin fragments F1+2 (F1+2) and free TF pathway inhibitor (f-TFPI). TF and FXIa activity were detected in 25 (20.2%) and 49 (39.5%) stable angina patients, respectively. Both factors were found in 23 (18.5%) patients. Patients with detectable TF or FXIa had higher F1+2, 8-iso-PGF(2α), IL-6, but not other cytokines, and lower f-TFPI (all P < 0.001) compared with the remainder. There were no intergroup differences with regard to cardiovascular risk factors or medication. Multivariate analysis showed that F1+2 ...Continue Reading
References
Aug 1, 1995·Circulation·E FalkV Fuster
Jul 4, 1998·Japanese Circulation Journal·K MisumiK Kumeda
Jun 9, 1999·Circulation·H SoejimaK Kumeda
Jan 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·L FontanaC Laudanna
Oct 23, 2001·Seminars in Thrombosis and Hemostasis·S Alban
Mar 13, 2002·Atherosclerosis·Christoph MerloBernhard Lämmle
Apr 12, 2002·Atherosclerosis·Hideaki KanedaMinoru Ohno
May 1, 2002·Circulation·Olaf HerkertAgnes Görlach
May 29, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Ø HetlandD W T Nilsen
Mar 17, 2004·Circulation·P E MorangeUNKNOWN PRIME Study Group
Apr 3, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Annelie SiegemundLothar Engelmann
Apr 10, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Simone J H WieldersTheo Lindhout
May 1, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Nigel Mackman
Sep 24, 2004·Circulation·Emmanouil ZouridakisJuan Carlos Kaski
Dec 1, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Anetta UndasKenneth G Mann
Jan 5, 2005·Journal of the American College of Cardiology·Valerio SanguigniFrancesco Violi
Jun 29, 2005·Circulation·Peter Libby, Pierre Theroux
Jul 6, 2005·Atherosclerosis·Bin WangYing Zou
Nov 4, 2005·Circulation·Myan TangDomenico Praticò
Feb 8, 2006·Circulation·Jan SteffelFelix C Tanner
May 5, 2006·Seminars in Thrombosis and Hemostasis·Harold R RobertsDougald M Monroe
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Donna L PedicordYuval Blat
Nov 16, 2007·Coronary Artery Disease·Ibrahim BasariciHuseyin Yilmaz
Jan 25, 2008·Thrombosis and Haemostasis·Saulius ButenasKenneth G Mann
Jul 10, 2008·Thrombosis and Haemostasis·Marc Schindewolf, Edelgard Lindhoff-Last
Apr 9, 2009·Blood·Dmitri V KravtsovDavid Gailani
May 30, 2009·Journal of cardiology·Epaminondas Zakynthinos, Nikolitsa Pappa
Jul 3, 2009·Thrombosis Journal·Birgit A SteppichIlka Ott
Citations
Feb 6, 2014·PloS One·Elena LipetsMikhail Panteleev
Oct 8, 2014·Thrombosis Research·R LoeffenH Ten Cate
Jan 31, 2015·Thrombosis Journal·Elena N Lipets, Fazoil I Ataullakhanov
Jul 16, 2016·PloS One·Rinske LoeffenHugo Ten Cate
Mar 23, 2017·The Journal of Trauma and Acute Care Surgery·Shannon M PriorSaulius Butenas
Oct 30, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Karin LeidermanAaron L Fogelson
Jul 28, 2021·European Journal of Clinical Investigation·Michał ZąbczykAnetta Undas