Sep 1, 1975

Factors causing lysis of an Actinomyces rimosus culture, the producer of the antibiotic, oxytetracycline

Ia I RautenshteĭnL N Moskalenko


The lysis of Actinomyces rimosus producing oxytetracycline during its mass growth can be caused by two factors which were separated by differential centrifugation. The first factor is phage particles of a temperate phage produced by the culture; they are incapable of growth but may induce the lysis. The phage particles treated with low pH and a temperature of 70 degrees C lose the lytic activity. The second factor is a lytic enzyme produced under the control of the temperate phage during its induction; it seems to consist of at least two enzymes, a lytic enzyme and a proteolytic enzyme.

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Mentioned in this Paper

Pathologic Cytolysis
Enzymes, antithrombotic
Oxytetracycline, (5 beta)-Isomer
Peptide Hydrolases
Proteolytic Enzyme

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