PMID: 6973324Jun 1, 1981Paper

Factors causing rickets in institutionalised handicapped children on anticonvulsant therapy

Archives of Disease in Childhood
Y Morijiri, T Sato

Abstract

An epidemiological study on vitamin D-dependent rickets was carried out in severely handicapped institutionalised children on long-term anticonvulsant therapy. Nine (10%) of 94 patients had overt rickets on the basis of roentgenological bone changes and biochemical indices, but 46 patients in hospital without medication, and 50 epileptic patients attending an outpatient clinic and taking anticonvulsants had no sign of rickets. Causative factors for the development of rickets were evaluated. Administration of anticonvulsive drugs depressed the serum 25-hydroxyvitamin D (25-OHD) level, but this was not the major factor in the development of rickets. Vitamin D intake seemed to be about average in these patients and its supplementation increased their serum 25-OHD level. This serum 25-OHD level was not maintained by supplemental vitamin D, unless the children were exposed to sunlight. These results indicate that although several factors--such as anticonvulsants, low vitamin D intake, and inactivity--are concerned in the development of rickets, the main cause is lack of sun in institutionalised handicapped children.

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Citations

May 18, 2004·Epilepsy & Behavior : E&B·Imran I AliJohn R Gates
Jan 1, 1984·Journal of the American College of Nutrition·M Gascon-BarréL H Lebrun
Jul 5, 2006·Journal of Pediatric Gastroenterology and Nutrition·Valerie MarchandUNKNOWN NASPGHAN Committee on Nutrition
Jun 3, 2009·Epilepsia·Giangennaro CoppolaMarco Salvatore
Dec 21, 2013·BMC Pediatrics·Herng-Sheng LeeHueng-Chuen Fan
Apr 1, 1986·Italian Journal of Neurological Sciences·E Beghi, R Di Mascio
Feb 6, 2016·Continuum : Lifelong Learning in Neurology·Chad Carlson, Christopher T Anderson
May 28, 2013·Journal of the Neurological Sciences·Kim BeerhorstAlbert P Aldenkamp
Aug 5, 2016·International Journal of Molecular Sciences·Hueng-Chuen FanChing-Shiang Chi
Jan 12, 2013·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kim RobienJill M Hamilton-Reeves
Feb 2, 2017·Paediatrics and International Child Health·Anju SethMuthuselvan Gopinath
Apr 16, 2004·The Annals of Pharmacotherapy·Fawzi Elhami AliFatema A Al-Mulla
Feb 24, 2006·Journal of Intellectual Disabilities : JOID·Timothy Siu Fu WongGenevieve Fung
Nov 28, 1997·Journal of Child Neurology·R C Henderson
Jan 1, 2011·Clinical Medicine Insights. Pediatrics·Jaclyn L OteroAllah Haafiz
Sep 1, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·E Erbayat AltayA Hasanoğlu
Jul 27, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Hasan TekgulSarenur Tutuncuoglu
May 28, 2020·International Journal of Environmental Research and Public Health·Hueng-Chuen FanHerng-Sheng Lee
Sep 1, 1996·Developmental Medicine and Child Neurology·P P Lin, R C Henderson
Aug 12, 2006·Journal of Child Neurology·Polyxeni NicolaidouThemistoklis Karpathios
Aug 24, 2021·Risk Management and Healthcare Policy·Michael Wakeman

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