Factors contributing to nasal allergic late phase eosinophilia

American Journal of Otolaryngology
Matthias F KramerGerd Rasp

Abstract

This study focused on factors contributing to eosinophilia after intranasal allergen challenge. Nasal secretions of 13 allergic individuals were gained over a period of 8 hours after nasal allergen challenge. Early and late phase reactions were determined by acoustic rhinometry and changes of volume and total protein in nasal secretions. Eosinophilia was demonstrated by nasal eosinophilic cationic protein. Interleukin (IL)-5; the chemokines IL-8, monocyte chemotactic protein (MCP)-1 and MCP-3, and eotaxin; soluble vascular cell adhesion molecule 1 (sVCAM-1); and the leukotriene C4 (LTC4) were analyzed by enzyme-linked immunosorbent assay for their suggested impacts on tissue eosinophilia. By means of rhinometry, we observed in 69% an alternating type of late phase response, followed by a bilateral (15%) or unilateral (8%) type. A biphasic kinetic could be demonstrated by changes in nasal volume and total protein of nasal secretions, reflecting the early and late phase responses. A typical late phase kinetic was observed for IL-5, MCP-1, eotaxin, sVCAM-1, and LTC4. Interleukin 8 was characteristic for early phase reaction but increased in late phase as well. We could not detect any MCP-3 in our samples. Our data point to a relev...Continue Reading

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Citations

Jul 15, 2009·World Journal of Gastroenterology : WJG·Arthur C OuwehandErika Isolauri
Mar 27, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S LópezM Blanca
Oct 3, 2009·The Journal of Allergy and Clinical Immunology·Carmen RondónMiguel Blanca
Oct 1, 2014·The Laryngoscope·Kent LamClaus-Peter Richter
Jun 8, 2017·The Annals of Otology, Rhinology, and Laryngology·Cveta Špadijer MirkovićDanilo Vojvodić
Dec 19, 2015·International Forum of Allergy & Rhinology·Aleksandar PerićDanilo Vojvodić
Apr 2, 2010·Allergy, Asthma & Immunology Research·Joo-Hee KimHae-Sim Park
Jul 17, 2018·Oxidative Medicine and Cellular Longevity·Ioana Adriana MunteanDiana Deleanu
Oct 23, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hee-Yun KimHyun-Ja Jeong

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