PMID: 4287844Mar 1, 1966Paper

Factors controlling amino acid incorporation by ribosomes from krebs II mouse ascites-tumour cells

The Biochemical Journal
I M KerrT S Work

Abstract

1. A ribosome-cell sap system capable of supporting the incorporation of (14)C-labelled amino acids into protein has been prepared from Krebs II mouse ascites-tumour cells. The requirements of this system for optimum activity and response to added messenger RNA have been investigated. One such system has been obtained for which amino acid incorporation is almost wholly dependent on the addition of suitable messenger RNA. 2. Ribosomes of widely different but predictable activities in the cell-free system have been prepared from Krebs cells pretreated in a variety of ways. The factors in the pretreatment of the cells responsible for these differences have been investigated. 3. The structural and functional properties of these different ribosome preparations and their response to exogenous messenger RNA have been examined and are discussed in the light of modern concepts of the control of protein synthesis.

Citations

Jun 9, 2017·Nature Communications·Sawsan NapthineAndrew E Firth
Jun 15, 1974·European Journal of Biochemistry·M Esteban, I M Kerr
Jan 14, 1972·Biochemical and Biophysical Research Communications·W K Roberts, W H Coleman
Dec 18, 1972·Biochemical and Biophysical Research Communications·G BeaudF Gros
May 16, 1970·Nature·A E Smith, K A Marcker
Jun 25, 1974·Journal of Molecular Biology·D T Simmons, J H Strauss
Jul 2, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hideto KawarataniHitoshi Yoshiji
Dec 10, 1971·European Journal of Biochemistry·J L Coote, T S Work
Dec 1, 1970·European Journal of Biochemistry·M Mathews, A Korner
May 14, 2003·Journal of Virology·Yuri V Svitkin, Nahum Sonenberg
Feb 1, 1970·Journal of Virology·I M KerrE M Martin
May 1, 1976·Journal of Virology·I M KerrD Baltimore
May 16, 1975·Biochimica Et Biophysica Acta·O K SharmaE Borek
Mar 18, 1977·Biochimica Et Biophysica Acta·R G Whalen, F Gros
Apr 1, 1971·Journal of Virology·I M Kerr
Jan 14, 1969·Journal of Molecular Biology·R H Burdon, A E Clason

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