PMID: 11899293Mar 20, 2002Paper

Factors controlling transduction signaling and proliferation of airway smooth muscle

Current Allergy and Asthma Reports
J L BlackC L Armour

Abstract

The airway smooth muscle cell is an active participant in the inflammatory response that accompanies asthma. It can interact with the epithelium and inflammatory cells to produce cytokines and cell surface molecule upregulation. Moreover, smooth muscle cells can alter the composition of the extracellular matrix proteins via changes in the production of matrix metalloproteinases and their tissue inhibitors. These properties may contribute to the increase in the amount of airway smooth muscle that characterizes the asthmatic airway wall and the remodeling that underlies the structural changes that lead to persistent asthma.

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Citations

Apr 16, 2004·Respiratory Research·Jeffrey J Fredberg
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·Steven S An, Jeffrey J Fredberg
Jan 26, 2008·Journal of Applied Physiology·Harley SyyongKuo H Kuo

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