PMID: 1201498Oct 1, 1975Paper

Factors determining the decay of K+ potentials and focal potentials in the central nervous system

Canadian Journal of Physiology and Pharmacology
K Krnjević, M E Morris

Abstract

Post-tetanic undershoots in extracellular focal potential (deltaV) and K+ potential (EK) can be recorded in the cuneate nucleus and dorsal horn of Dial-anaesthetized or decerebrate cat. They are seen best at depths where the largest deltaEK and deltaV are recorded and they increase with the frequency and duration of stimulation. The very different time courses of undershoots of deltaV and deltaEK indicate two hyperpolarizing influences: first, electrogenic pumping, and later, a reduced external K+ concentration. The importance of active K+ removal in determining the amplitude and duration of deltaEK and deltaV is illustrated by their marked potentiation (as well as the disappearance of post-tetanic undershoots) induced by a lowering of blood pressure or local application of strophanthidin.

Citations

Mar 1, 1984·Pflügers Archiv : European journal of physiology·M GalvanR Rick
Nov 1, 1982·Pflügers Archiv : European journal of physiology·A UllrichG ten Bruggencate
Sep 1, 1979·Electroencephalography and Clinical Neurophysiology·M J GutnickH D Lux
Jan 1, 1983·Progress in Biophysics and Molecular Biology·E Syková
Jan 1, 1977·Progress in Neurobiology·R A Levy
Mar 1, 1988·Journal of Pharmacological Methods·K H ReidA Wauquier
Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·N SchechterJ Schmidt
Aug 25, 2015·Progress in Neurobiology·Kaviraja Udupa, Robert Chen
Nov 6, 2012·The European Journal of Neuroscience·Alexander C SuttonDamian S Shin
Sep 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T J SickS I Harik
Apr 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S J MilitoT J Sick
Jul 1, 1988·Pflügers Archiv : European journal of physiology·E SykováN Kríz
Jan 1, 1990·Annals of the New York Academy of Sciences·N E Naftchi
Jan 11, 2002·Journal of Neurophysiology·Raimondo D'AmbrosioH Richard Winn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.