Factors effect on the loading efficiency of Vitamin C loaded chitosan-coated nanoliposomes

Colloids and Surfaces. B, Biointerfaces
Nan Liu, Hyun-Jin Park

Abstract

Chitosan-coated nano-size liposomes as a new carrier with bioactivity were made from phosphatidylcholine (pc) and cholesterol (chol) by direct injection. Liposomes prepared using ethanol as a solvent with pc:chol ratios of 40:60 and 60:40 displayed mall mean diameters (97.4nm and 95.8nm, respectively). Different factors affecting the loading efficiency and payload of Vitamin C for these nano-size liposomes were investigated by high-pressure liquid chromatography. Liposomes prepared with a pc:chol ratio of 60:40 were promising Vitamin C carriers with a maximum loading efficiency about 96.5% and payload about 46.82%. When liposomes were prepared with 100mg initial mass of Vitamin C, maximum loading efficiency was obtained. Furthermore, with an increasing initial mass of Vitamin C, the payload increased. Based on the experimental results, it appears that the chitosan concentration does not affect the loading efficiency and payload of liposomes. Liposomes prepared under the above optimum conditions were stable during 15 weeks storage such that over 85% Vitamin C was protected against oxidation.

References

Jun 1, 2000·Biochimica Et Biophysica Acta·Y Perrie, G Gregoriadis
Feb 1, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jong-Ho KimIck Chan Kwon

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Citations

Oct 3, 2013·International Journal of Molecular Sciences·Shuibing YangYaqin Hu
Aug 14, 2012·Journal of Liposome Research·Hsiao Wei Tan, Misni Misran
Jan 23, 2013·International Journal of Pharmaceutics·Mohamed A El-NabarawiMohammed Y S Abary
Oct 15, 2013·Journal of Tissue Engineering and Regenerative Medicine·Nelson MonteiroNuno M Neves
Nov 24, 2012·International Journal of Pharmaceutics·Hsiao Wei Tan, Misni Misran
Jan 29, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Arthur de Castro Jorge SilvaTiago Collares
Jan 27, 2017·Annual Review of Food Science and Technology·Rohollah SadeghiJozef L Kokini
Jan 26, 2017·Chemical Biology & Drug Design·Fateme HaghiralsadatTymour Forouzanfar
Dec 9, 2020·Antioxidants·Marco B MorelliGaetano Santulli

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