PMID: 44701Nov 1, 1979

Factors influencing adherence of group B streptococci to human vaginal epithelial cells

Infection and Immunity
S M ZawanehW N Spellacy

Abstract

Factors affecting the adherence of group B streptococci to human vaginal epithelial cells in vitro were examined. Maximal adherence was achieved within 15 min of incubation of bacteria with epithelial cells. Adherence was temperature and pH dependent; maximal adherence occurred at 37 degrees C and pH 5.5. Killing of streptococci with ultraviolet light or penicillin did not affect adherence. Similarly, adherence was not altered by preincubating epithelial cells at 65 degrees C for 30 min. Thus neither bacterial nor epithelial cell viability appears to be a prerequisite for adherence. Preincubation of streptococci at 65 degrees C for 30 min resulted in a marked decrease in adherence, whereas preincubation of group B streptococci with neuraminidase was associated with a significant increase in adherence. The adherence of strains belonging to five different group B streptococcal serotypes was not altered by group-specific or type-specific rabbit antisera. These findings suggest that the site for adherence on the bacterial cell wall is heat sensitive and is marked by sialic acid, but is not related to either group-specific or type-specific antigens.

Citations

Feb 4, 2014·Applied and Environmental Microbiology·Nunzia D'UrzoMembers of the DEVANI Study Group
Jan 1, 1983·Folia Microbiologica·V KubínJ Franĕk
Oct 27, 2004·Infection and Immunity·Axel SchubertDieter J Reinscheid
Dec 22, 2005·Respiration; International Review of Thoracic Diseases·Funda OztunaMurat Topbaş
Jan 1, 1993·Urological Research·T C Gasser, P O Madsen
May 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J KällmanE Kihlström
Mar 9, 2005·The Journal of Biological Chemistry·Thierry C AupérinJames M Hogle
Aug 1, 2020·Frontiers in Cellular and Infection Microbiology·Tingjun LiuLihong Guo
Jan 1, 1980·Infection·B Sugarman
Feb 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M Granlund-EdstedtS Hakansson
Nov 26, 2003·Infection and Immunity·Atul K JohriLawrence C Paoletti
Jul 14, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·P DadvandM J Nieuwenhuijsen
Sep 23, 2017·Frontiers in Cellular and Infection Microbiology·Sarah Shabayek, Barbara Spellerberg
Mar 30, 2018·Frontiers in Microbiology·Sarah Shabayek, Barbara Spellerberg

Related Concepts

Adhesiveness
Mesothelium
Melting
Hydrogen-Ion Concentration
Immune Sera
Mucins
Neuraminidase
Sialic Acids
Streptococcus agalactiae
Vagina

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