Factors Influencing Aqueous Proinflammatory Cytokines and Growth Factors in Uveitic Glaucoma

PloS One
Saori OhiraHidenobu Tanihara

Abstract

To analyze the effects of factors on aqueous humor proinflammatory cytokine and growth factor levels in patients with uveitic glaucoma (UG). In this cross-sectional study, we enrolled 143 participants: 1) UG patients (n = 39); 2) primary open-angle glaucoma (POAG) patients (n = 36); and 3) cataract surgery patients, as a comparative group (n = 68). Aqueous humor samples were obtained at the start of surgery. Aqueous cytokine levels were determined using a multiplex immunoassay (xMAP and the Human Cytokine/Chemokine Panel I). In UG cases, mean interleukin (IL)-6, IL-8, monocyte chemotactic protein (MCP)-1, tumor necrosis factor (TNF)-α, platelet-derived growth factor (PDGF)-AA, PDGF-AB/BB, and VEGF levels were 171.1, 214.5, 2791.7, 3.5, 23.9, 5.4, and 168.9 pg/mL, respectively, and were higher than those in cataract (non-glaucomatous) cases except PDGF. Levels of IL-6, MCP-1, and VEGF were higher in UG cases than in POAG cases. UG cases with a history of phacoemulsification displayed significantly higher levels of IL-6 (P = 0.0164), IL-8 (P = 0.0003), MCP-1 (P = 0.0465), and PDGF-AB/BB (P = 0.0062) compared to the phakic cases. The presence of cells in the anterior chamber was related to higher levels of IL-8 (P = 0.0002), TNF-α...Continue Reading

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Citations

Dec 26, 2016·Survey of Ophthalmology·Roly Megaw, Pankaj Kumar Agarwal
May 13, 2018·The Journal of Biological Chemistry·Miyuki Inoue-MochitaHidenobu Tanihara
Nov 13, 2020·International Reviews of Immunology·Pachiappan Arjunan
Feb 26, 2021·Frontiers in Pharmacology·Shahid HusainShikhar Mehrotra
Mar 24, 2021·The British Journal of Ophthalmology·Ruyi ZhaiXinghuai Sun
Apr 17, 2021·Clinical Ophthalmology·Moustafa S MagliyahHassan Al-Dhibi
Jul 24, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jin-Ho KimJin A Choi
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May 18, 2020·Archivos de la Sociedad Española de Oftalmología·Z S Ulhaq, G V Soraya
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Software Mentioned

JMP
DNASIS Plex
GraphPad Prism

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