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Factors influencing ascertainment bias of microsatellite allele sizes: impact on estimates of mutation rates

Genetics

Aug 16, 2013

Biao Li, M Kimmel

Abstract

Microsatellite loci play an important role as markers for identification, disease gene mapping, and evolutionary studies. Mutation rate, which is of fundamental importance, can be obtained from interspecies comparisons, which, however, are subject to ascertainment bias. This bias arises...read more

Mentioned in this Paper

Genetic Drift
Short Tandem Repeat
Computer Programs and Programming
Pan troglodytes
Underpopulation
Pan Genus
Locus
Alleles
Evolution, Neutral
Tetranucleotide Repeats
Paper Details
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Factors influencing ascertainment bias of microsatellite allele sizes: impact on estimates of mutation rates

Genetics

Aug 16, 2013

Biao Li, M Kimmel

PMID: 23946335

DOI: 10.1534/genetics.113.154161

Abstract

Microsatellite loci play an important role as markers for identification, disease gene mapping, and evolutionary studies. Mutation rate, which is of fundamental importance, can be obtained from interspecies comparisons, which, however, are subject to ascertainment bias. This bias arises...read more

Mentioned in this Paper

Genetic Drift
Short Tandem Repeat
Computer Programs and Programming
Pan troglodytes
Underpopulation
Pan Genus
Locus
Alleles
Evolution, Neutral
Tetranucleotide Repeats

Trending Feeds

Blastomycosis

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Related Papers

Molecular Biology and Evolution

A power analysis of microsatellite-based statistics for inferring past population growth

Molecular Biology and EvolutionDecember 9, 2000
J P KingR Chakraborty
American Journal of Human Genetics

Divergence between human populations estimated from linkage disequilibrium

American Journal of Human GeneticsNovember 18, 2008
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Paper Details
References
  • References
  • Citations10
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations10
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