PMID: 2895071Mar 1, 1988Paper

Factors influencing blood pressure and heart rate variability in hypertensive humans

Hypertension
John S FlorasP Sleight

Abstract

We examined the influence of baroreceptor reflex sensitivity (the increase in pulse interval in response to a phenylephrine-induced increase in blood pressure), age, blood pressure, and beta-adrenergic receptor blockade on the variability of blood pressure and heart rate in essential hypertension. Fifty-six subjects were studied before treatment; intra-arterial blood pressure was recorded outside the hospital for 24 hours. Variability was defined (from all beats occurring while subjects were awake) as the standard deviation about the average waking value for mean arterial pressure (MAP) or pulse interval. The correlation (r) between baroreceptor reflex sensitivity and blood pressure variability was -0.47 (p less than 0.0002). Baroreceptor reflex sensitivity was the only independent determinant of blood pressure variability on multiple regression analysis. Thirty subjects were restudied after 5 months of beta-adrenergic receptor blockade. Ambulatory blood pressure was lower during treatment, whereas pulse interval, its variability, and baroreceptor reflex sensitivity were higher. Blood pressure variability was unchanged. The variability of MAP was inversely correlated with baroreceptor reflex sensitivity before (r = -0.42, p les...Continue Reading

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Citations

Nov 26, 2005·The International Journal of Cardiovascular Imaging·Paul Steendijk
Mar 1, 1994·Journal of the Autonomic Nervous System·M KollaiA Naszlady
Oct 1, 1993·Journal of the American College of Cardiology·John S Floras
Nov 1, 1996·Archives of Gerontology and Geriatrics·F RengoCHF Italian Study Investigators
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Dec 3, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Narimasa TakayamaTsutomu Imaizumi
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Jan 14, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masato EtoYasuyoshi Ouchi
Jun 23, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masato EtoYasuyoshi Ouchi
Jun 17, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Osamu TochikuboKiyoko Nishijima
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May 16, 2002·Journal of Hypertension·John S Floras
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Aug 14, 2008·Journal of Hypertension·Christopher T ChanJohn S Floras
Jul 14, 2010·Journal of Hypertension·Giuseppe Schillaci, Gianfranco Parati
Dec 1, 1988·Journal of the Autonomic Nervous System·John S FlorasP Sleight
Aug 25, 2012·Clinical and Experimental Hypertension : CHE·Matthew R ElliottJamie P Dwyer
Jul 9, 2005·The Journal of Physiology·Dwain L Eckberg, Tom A Kuusela
May 2, 1990·The American Journal of Cardiology·J Ocon, J Mora
Jul 1, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuji AokiTsutomu Imaizumi
Jun 27, 2015·The Canadian Journal of Cardiology·John S Floras
Apr 27, 2013·The Canadian Journal of Cardiology·John S Floras
Jun 16, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazuki ShiinaAkira Yamashina
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Mar 3, 2010·Hypertension·Robert P NolanMaggie H Chen

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