Factors influencing cardiovascular risk following termination of glucocorticoid therapy for nephrotic syndrome.

Clinical and Experimental Nephrology
Akio NakamuraYukishige Yanagawa

Abstract

This study attempted to identify the cardiovascular risk factors associated with retention of excess weight following termination of glucocorticoid therapy in children with nephrotic syndrome. We performed a retrospective study of 30 Japanese children (18 males, 12 females, aged 1-14 years) who had been treated with glucocorticoids for steroid-sensitive nephrotic syndrome and 32 control children (17 males, 15 females, aged 1-15 years). The subjects receiving glucocorticoid therapy were divided into a retention group (n = 14) or a reduction group (n = 16) on the basis of the presence or absence of a maintained body mass index (BMI) following glucocorticoid termination. BMI z-scores, age, gender, blood pressure, serum total cholesterol levels (T-cho), and the dose and duration of glucocorticoid exposure were evaluated in each group during the study period. The retention group had a significantly (P < 0.05) increased dose and duration of glucocorticoid exposure, and of T-cho at the time of last visit compared with the control or reduction group. Moreover, logistic regression analysis showed that the adjusted odds ratio for T-cho at the time of last visit in the retention group was significantly higher (P < 0.05) relative to the re...Continue Reading

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Citations

Sep 17, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cengiz CandanSalim Çalışkan
Dec 25, 2012·Autoimmunity Reviews·Luciana P C SeguroYehuda Shoenfeld
Dec 18, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cláudia AlvesMaria Glória Rodrigues-Machado
Jun 19, 2021·Vascular Health and Risk Management·Heba Mostafa AhmedOsama Ezzat Botrous

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