Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study

Investigative Ophthalmology & Visual Science
Haomin LuoClaude F Burgoyne

Abstract

To quantify the influence of ocular and demographic factors on central laminar depth (LD) in healthy participants. A total of 362 normal subjects underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head (ONH) with a 24 radial B-scan pattern aligned to the fovea-to-Bruch's membrane opening (BMO) axis. BMO, anterior lamina, anterior scleral canal opening (ASCO), Bruch's membrane (BM), and the peripapillary scleral surface were manually segmented. The extent of laminar segmentation was quantified within 72 ASCO subsectors. Central LD was quantified relative to four reference planes: BMO, ASCO, BM, and scleral. The effects of age, sex, ethnicity, IOP, BMO area, ASCO area, and axial length on LD were assessed. Laminar visibility was most consistent within the central ASCO (median 89%, range, 69%-95%). LDBMO and LDBM were significantly shallower in eyes with greater age, BMO area, and axial length and in females. LDASCO was shallower in eyes with greater ASCO area and axial length and in European and Hispanic descent compared to African descent eyes. LDSclera behaved similarly, but was not associated with axial length. BMO and ASCO area were not different between African descent and European descent...Continue Reading

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Citations

Sep 8, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Brad Fortune
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Feb 28, 2019·Investigative Ophthalmology & Visual Science·Hongli YangClaude F Burgoyne
Jan 3, 2019·Investigative Ophthalmology & Visual Science·Brad Fortune
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Nov 10, 2020·American Journal of Ophthalmology·Eugene A LowryBrad Fortune
Feb 4, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Sevcan Balci, Ece Turan-Vural

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