Factors influencing choices of empirical antibiotic treatment for bacterial infections in a scenario-based survey in Vietnam

JAC-antimicrobial Resistance
Thi Lan Huong VuH Rogier van Doorn

Abstract

Antimicrobial stewardship (AMS) programmes have been implemented around the world to guide rational use of antibiotics but implementation is challenging, particularly in low- and middle-income countries, including Vietnam. Understanding factors influencing doctors' prescribing choices for empirical treatment can help design AMS interventions in these settings. To understand doctors' choices of antibiotics for empirical treatment of common bacterial infections and the factors influencing decision-making. We conducted a cross-sectional survey among medical professionals applying for a postgraduate programme at Hanoi Medical University, Vietnam. We used a published survey developed for internal medicine doctors in Canada. The survey was self-administered and included four clinical scenarios: (i) severe undifferentiated sepsis; (ii) mild undifferentiated sepsis; (iii) severe genitourinary infection; and (iv) mild genitourinary infection. A total of 1011/1280 (79%), 683/1188 (57.5%), 718/1157 (62.1%) and 542/1062 (51.0%) of the participants selected combination therapy for empirical treatment in scenarios 1, 2, 3 and 4, respectively. Undifferentiated sepsis (OR 1.82, 95% CI 1.46-2.27 and 2.18, 1.51-3.16 compared with genitourinary) ...Continue Reading

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Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

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