Factors influencing conformity index in radiotherapy for non-small cell lung cancer

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
Sinead M BrennanJohn Armstrong

Abstract

The radiotherapy conformity index (CI) is a useful tool to quantitatively assess the quality of radiotherapy treatment plans, and represents the relationship between isodose distributions and target volume. A conformity index of unity implies high planning target volume (PTV) coverage and minimal unnecessary irradiation of surrounding tissues. We performed this analysis to describe the CI for lung cancer 3-dimensional conformal radiotherapy (3DCRT) and to identify clinical and technical determinants of CI, as it is not known which factors are associated with good quality 3D conformal radiotherapy treatment planning. Radiotherapy treatment plans from a database of 52 patients with inoperable Stage 1 to 3b lung cancer, on a hypofractionated 3DCRT trial were evaluated. A CI was calculated for all plans using the definition of the ICRU 62:CI = (TV/PTV), which is the quotient of the treated volume (TV) and the PTV. Data on patient, tumor, and planning variables, which could influence CI, were recorded and analyzed. Mean CI was 2.01 (range = 1.06-3.8). On univariate analysis, PTV (p = 0.023), number of beams (p = 0.036), medial vs. lateral tumor location (p = 0.016), and increasing tumor stage (p = 0.041) were associated with improve...Continue Reading

References

Dec 1, 1995·International Journal of Radiation Oncology, Biology, Physics·R J HamiltonG T Chen
Mar 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Hasan MurshedJoe Y Change
Apr 28, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierre ThirionJohn Armstrong
Jan 18, 2006·International Journal of Radiation Oncology, Biology, Physics·Loïc FeuvretPierre Bey

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