PMID: 2492223Jan 1, 1989Paper

Factors influencing effectiveness of thyrotropin-releasing hormone therapy for severe epilepsy in childhood: significance of serum prolactin levels

Epilepsia
A MatsumotoK Watanabe

Abstract

Various factors possibly influencing responsiveness to thyrotropin-releasing hormone (TRH) therapy were studied in 38 children (20 M, 18 F) with severe epilepsy. Mean age at treatment was 4.7 years (range; 0-18 years). Seizure type was infantile spasms (IS) in 16, generalized tonic seizures in 8, secondarily generalized partial seizures in 4, generalized tonic-clonic seizures in 2, atypical absence in 5, myoclonic seizures in 1, and atonic seizures in 2 cases. All seizure types were classified by ictal EEGs documented by simultaneous EEG-VTR according to the International Classification of seizures, except for two with atonic seizures and one with IS. Factors analyzed were sex, age, etiology, neurologic abnormality, seizure types, seizure frequency, EEGs, duration of TRH therapy, and serum hormone [human growth hormone (HGH), prolactin (PRL), thyroid-stimulating hormone (TSH)] levels before and after TRH therapy. We showed that: (a) serum PRL level was significantly correlated to effectiveness of TRH therapy (the higher the PRL, the greater the response rate); (b) serum basal PRL decreased significantly, especially in good responders; and (c) serum basal PRL was elevated especially in patients with IS, which responded more to T...Continue Reading

Citations

Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·N Garcia-CairascoK O Nonaka
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael J KubekMichael C Veronesi
Jan 30, 2002·Pediatric Neurology·Michael J Kubek, Bhuwan P Garg
Jul 3, 1998·Pediatric Neurology·C TanakaK Takeshita
Jul 20, 2002·Bioorganic & Medicinal Chemistry Letters·Katalin Prokai-TatraiLaszlo Prokai
Mar 1, 1995·Journal of Child Neurology·K Watanabe

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