Factors influencing inadequate or suboptimal response to adefovir with or without genotypic resistance

Journal of Medical Virology
Xia ZhouYuMing Wang

Abstract

The aim of the study was to explore the factors in inadequate-responders to treatment with adefovir (ADV) with or without genotypic resistance. The reverse-transcriptase (RT) gene of hepatitis B virus (HBV) was sequenced in 161 patients with inadequate-response to ADV and analyzed for HBV genotypes using a phylogenetic approach. Seventy-six patients (47.2%) were found to carry the rtA181V/T/S or rtN236T residue substitution, and most of them had viral rebound. In the patients with viral rebound and ADV genotypic resistance, 19 (25.7%) showed rtA181V/T/S + rtN236T substitutions. In the other patients, it was found that HBV genotypes and cirrhosis influenced the selection of ADV-resistant positions by univariate analysis and multiple logistic regression analysis. The rtN236T was more frequent in patients with genotype B, and the rtA181V/T/S was more common in patients with genotype C (χ(2)  = 11.543, P = 0.001). Multiple logistic regression analysis showed that the rtN236T and time resistant strains occurred during ADV-treatment were statistically significant for influencing rtA181 variation types (P = 0.007 and P = 0.024, respectively), and the occurrence of rtA181T was found to be significantly earlier than rtA181V. In conclusi...Continue Reading

References

Jul 19, 2002·The Journal of General Virology·Patricia Arauz-RuizLars O Magnius
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christopher E WestlandUNKNOWN 437 and 438 Study Teams
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bernhard ZöllnerHeinz-Hubert Feucht
Jan 18, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Bernard Weber
Feb 17, 2005·Journal of the National Cancer Institute·Ming-Whei YuChien-Jen Chen
Dec 13, 2005·Journal of Hepatology·Scott K FungAnna S F Lok
Feb 4, 2006·Journal of Hepatology·Tim ShawStephen Locarnini
Apr 20, 2006·Journal of Medical Virology·A Bartholomeusz, S Locarnini
Apr 28, 2006·The New England Journal of Medicine·Oliver SchildgenWolfram H Gerlich
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoon-Seon LeeSoo-Ok Kim
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Florian van BömmelThomas Berg
Oct 3, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Oliver SchildgenWolfram Gerlich
Apr 25, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jing YuanMasashi Mizokami
Jun 29, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S LokUNKNOWN Hepatitis B Virus Drug Resistance Working Group
Jul 14, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Zhanhui WangJinlin Hou
Oct 17, 2008·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Jm Conly, Bl Johnston
Dec 2, 2008·Journal of Hepatology·Valentina SvicherCarlo Federico Perno

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.