Abstract
The aim of the study was to explore the factors in inadequate-responders to treatment with adefovir (ADV) with or without genotypic resistance. The reverse-transcriptase (RT) gene of hepatitis B virus (HBV) was sequenced in 161 patients with inadequate-response to ADV and analyzed for HBV genotypes using a phylogenetic approach. Seventy-six patients (47.2%) were found to carry the rtA181V/T/S or rtN236T residue substitution, and most of them had viral rebound. In the patients with viral rebound and ADV genotypic resistance, 19 (25.7%) showed rtA181V/T/S + rtN236T substitutions. In the other patients, it was found that HBV genotypes and cirrhosis influenced the selection of ADV-resistant positions by univariate analysis and multiple logistic regression analysis. The rtN236T was more frequent in patients with genotype B, and the rtA181V/T/S was more common in patients with genotype C (χ(2) = 11.543, P = 0.001). Multiple logistic regression analysis showed that the rtN236T and time resistant strains occurred during ADV-treatment were statistically significant for influencing rtA181 variation types (P = 0.007 and P = 0.024, respectively), and the occurrence of rtA181T was found to be significantly earlier than rtA181V. In conclusi...Continue Reading
References
Jul 19, 2002·The Journal of General Virology·Patricia Arauz-RuizLars O Magnius
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christopher E WestlandUNKNOWN 437 and 438 Study Teams
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bernhard ZöllnerHeinz-Hubert Feucht
Sep 15, 2004·Journal of Clinical Microbiology·Man-Fung YuenChing-Lung Lai
Jan 18, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Bernard Weber
Feb 17, 2005·Journal of the National Cancer Institute·Ming-Whei YuChien-Jen Chen
Jun 30, 2005·Journal of Viral Hepatitis·D N MoskovitzE J Heathcote
Dec 13, 2005·Journal of Hepatology·Scott K FungAnna S F Lok
Feb 4, 2006·Journal of Hepatology·Tim ShawStephen Locarnini
Apr 20, 2006·Journal of Medical Virology·A Bartholomeusz, S Locarnini
Apr 28, 2006·Journal of Viral Hepatitis·P HalfonP Cacoub
Apr 28, 2006·The New England Journal of Medicine·Oliver SchildgenWolfram H Gerlich
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoon-Seon LeeSoo-Ok Kim
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Florian van BömmelThomas Berg
Oct 3, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Oliver SchildgenWolfram Gerlich
Apr 25, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jing YuanMasashi Mizokami
Jun 15, 2007·Journal of Hepatology·M ButiR Esteban
Jun 29, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S LokUNKNOWN Hepatitis B Virus Drug Resistance Working Group
Jul 14, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Zhanhui WangJinlin Hou
Aug 19, 2007·Journal of Hepatology·Katyna Borroto-EsodaSarah Arterburn
Oct 12, 2007·Journal of Viral Hepatitis·X P PanJ F Sheng
Oct 17, 2008·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Jm Conly, Bl Johnston
Dec 2, 2008·Journal of Hepatology·Valentina SvicherCarlo Federico Perno
Mar 1, 2010·Journal of Viral Hepatitis·L J LiuL Wei