Factors influencing local and systemic levels of plasma myeloperoxidase in ST-segment elevation acute myocardial infarction

The American Journal of Cardiology
Catriona J MarshallDougal R McClean

Abstract

Myeloperoxidase (MPO) is associated with risk in acute coronary syndromes. However, the precise role it plays in ST-elevation myocardial infarction (STEMI) remains unclear. In this study we tested the hypothesis that levels of MPO in plasma after a myocardial infarction are affected by its ability to bind to the endothelium and there is local release of the enzyme at the culprit lesion. We measured plasma MPO in systemic circulation and throughout the coronary circulation in patients with STEMI undergoing primary percutaneous coronary intervention (PCI). MPO levels at the femoral artery were higher (p <0.001) in patients with STEMI (n = 67, median 45 ng/ml, interquartile range 34 to 83) compared to control patients (n = 12, 25 ng/ml, 19 to 30) with chronic stable angina undergoing elective PCI. After administration of the anticoagulant bivalirudin in 13 patients with STEMI, plasma MPO was increased only at the culprit coronary artery lesion before PCI (178 ng/ml, 91 to 245) versus all other sites (femoral artery 86 ng/ml, 54 to 139, p = 0.019). Administration of heparin caused a marked increase of plasma MPO. Even so, it was still possible to detect an increase of plasma MPO at culprit lesion in patients with STEMI (n = 54, 171...Continue Reading

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Citations

Jan 27, 2011·The Journal of Biological Chemistry·Flavia C MeottiAnthony J Kettle
Oct 18, 2011·Archives of Medical Research·Yongle ChenXianhong Shu
Jun 13, 2014·Clinical Physiology and Functional Imaging·Caroline Le GoffJean-Louis Croisier
Feb 15, 2015·European Heart Journal. Acute Cardiovascular Care·Ignacio M SeropianAntonio Abbate
Jan 8, 2017·Clinical Chemistry·Timothy C R PrickettA Mark Richards

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