Abstract
The study identified factors predisposing to non-albicans candidemia with special interest to prior antimicrobial treatment. A retrospective, case-case-control study was performed at the University Hospital of Heraklion, Greece, from November 2007 through September 2011 including adult patients. The study had three groups. The first included 58 patients with non-albicans candidemia, the second 48 with C. albicans candidemia, while the third (control) 104 without candidemia. Each of the two candidemia groups was compared with the control using multivariate logistic regression model. The mean (SD) age of the non-albicans, the albicans and the control patients was 67 (12), 67 (18) and 59 (19) years, respectively. The most common non-albicans Candida spp. isolated were C. parapsilosis in 19 patients (33%), C. glabrata in 17 (29%) and C. tropicalis in 15 (26%). Independent risk factors for non-albicans candidemia were prior treatment with quinolones (p < 0.001), b-lactam-b-lactamase inhibitors (p = 0.011) and presence of central venous catheter (p = 0.05), while for C. albicans candidemia were prior treatment with quinolones (p < 0.001), carbapenems (p = 0.003) along with cardiac disease (p < 0.001). Neither duration of hospitalizat...Continue Reading
References
Sep 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·V J FraserW C Dunagan
Jan 1, 1993·Antimicrobial Agents and Chemotherapy·G SamonisG P Bodey
May 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G T ColeE J Anaissie
Oct 3, 1998·Antimicrobial Agents and Chemotherapy·A S OrozcoS G Filler
Aug 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C ViscoliF Meunier
Aug 25, 1999·Diagnostic Microbiology and Infectious Disease·A L ColomboS B Wey
Feb 5, 2002·The Journal of Hospital Infection·W HopeD P Eisen
Jan 30, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M A PfallerUNKNOWN International Fungal Surveillance Participant Group
Apr 9, 2004·Journal of Clinical Microbiology·Rana A HajjehDavid W Warnock
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Nicole J PultzCurtis J Donskey
May 4, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Keith S KayeYehuda Carmeli
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Theoklis E ZaoutisChris Feudtner
Oct 28, 2005·Antimicrobial Agents and Chemotherapy·Michael Y LinStephen G Weber
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brad J SpellbergJohn E Edwards
May 17, 2006·Medical Mycology·G SamonisE Mantadakis
Mar 22, 2007·The Annals of Pharmacotherapy·Susan L DavisPeggy S McKinnon
Jan 30, 2008·Anesthesia and Analgesia·George DimopoulosMatthew E Falagas
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer K ChowSusan Hadley
Mar 12, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D RodríguezUNKNOWN Barcelona Candidemia Project Study Group
May 26, 2010·Antimicrobial Agents and Chemotherapy·José Garnacho-MonteroCarlos Ortiz-Leyba
Jul 29, 2010·Medical Mycology·Nur YaparOnur Kaya
Nov 27, 2010·Medical Mycology·S MarakiG Samonis
Apr 29, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hung-Wei ChiJung-Chung Lin
Feb 9, 2012·Antimicrobial Agents and Chemotherapy·Ronen Ben-AmiUNKNOWN Israeli Candidemia Study Group
Citations
Dec 25, 2019·Antimicrobial Agents and Chemotherapy·Maria SiopiJoseph Meletiadis
May 23, 2019·BMC Infectious Diseases·C KeighleyM A Slavin
Sep 10, 2018·Infection·Matthaios Papadimitriou-OlivgerisMyrto Christofidou
Oct 30, 2019·Open Forum Infectious Diseases·Tsubasa AkazawaNorio Ohmagari
Nov 14, 2020·Mycoses·Caitlin Livia KeighleySharon C-A Chen
Jan 23, 2021·Pathogens·Aline El ZakhemSouha S Kanj
Dec 23, 2021·Internal Medicine Journal·Caitlin KeighleyUNKNOWN Australasian Antifungal Guidelines Steering Committee