Factors Influencing Optical Coherence Tomography Peripapillary Choroidal Thickness: A Multicenter Study

Investigative Ophthalmology & Visual Science
Hongli YangClaude F Burgoyne

Abstract

To quantify peripapillary choroidal thickness (PCT) and the factors that influence it in healthy participants who represent the racial and ethnic composition of the U.S. population. A total of 362 healthy participants underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head with a 24 radial B-scan pattern aligned to the fovea to Bruch's membrane opening axis. Bruch's membrane, anterior scleral canal opening (ASCO), and the anterior scleral surface were manually segmented. PCT was measured at 100, 300, 500, 700, 900, and 1100 μm from the ASCO globally and within 12 clock-hour sectors. The effects of age, axial length, intraocular pressure, ethnicity, sex, sector, and ASCO area on PCT were assessed by ANOVA and univariable and multivariable regressions. Globally, PCT was thicker further from the ASCO border and thinner with older age, longer axial length, larger ASCO area, European descent, and female sex. Among these effectors, age and axial length explained the greatest proportion of variance. The rate of age-related decline increased further from the ASCO border. Sectorally, the inferior-temporal sectors were thinnest (10.7%-20.0% thinner than the thickest sector) and demonstrated a higher ra...Continue Reading

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Citations

Feb 23, 2020·Investigative Ophthalmology & Visual Science·Gyu-Nam KimTae-Woo Kim
Sep 10, 2019·Investigative Ophthalmology & Visual Science·Min Hee SuhRupesh Agrawal
Nov 13, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ebru N CetinGökhan Pekel
Apr 25, 2021·Scientific Reports·Jasmin RezapourLinda M Zangwill
May 26, 2021·Japanese Journal of Ophthalmology·Hitomi ShibataTakeshi Iwase

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Software Mentioned

GEEGLM
Heyex
ATL 3D Suite
Matlab
R

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