Factors influencing oral anticoagulant use in patients newly diagnosed with atrial fibrillation.

European Journal of Clinical Investigation
Woldesellassie M BezabheGregory M Peterson

Abstract

We investigated factors that influenced oral anticoagulant (OAC) initiation and choice in Australian general practice patients newly diagnosed with AF. Using an Australian nationally representative general practice dataset, MedicineInsight, we identified patients newly diagnosed with AF between January 2009 and April 2019. Logistic regression analyses were used to examine factors associated with OAC initiation and choice. A total of 63 212 patients with AF (53.7% males, mean age 72.4 years) were identified. Nearly two-thirds of these patients (40 854 [64.6%]) were initiated on an OAC, at a median time of 6 days after the documented diagnosis date. The proportion of patients who were initiated an OAC increased from 44.8% in 2009 to 72.2% in 2019 (P < .001). High risk of stroke (CHA2 DS2 -VASc, adjusted odds ratio (AOR), 4.39 [95% CI, 3.99-4.83]), low risk of bleeding (ORBIT, AOR, 1.87 [95% CI, 1.72-2.03]), not having a recorded history of dementia (AOR, 1.81 [95% CI, 1.65-1.98]) and male sex (AOR, 1.29 [95% CI, 1.22-1.35]) were independently associated with OAC initiation. Direct-acting oral anticoagulant (DOAC) use increased from 11.9% in 2011 to 94.0% of all OAC initiations in April 2019 (P < .001). The proportion of newly dia...Continue Reading

References

Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Jan 9, 2010·European Journal of Clinical Investigation·I SimeraD G Altman
Mar 18, 2010·Circulation. Cardiovascular Quality and Outcomes·Greg C FlakerUNKNOWN Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE) Investigators
Dec 19, 2013·Circulation·Sumeet S ChughChristopher J L Murray
Jan 16, 2015·The Medical Journal of Australia·Jocasta BallSimon Stewart
Mar 11, 2015·International Journal of Clinical Practice·E ShantsilaD A Lane
Jun 25, 2016·Journal of the American College of Cardiology·Jonathan C HsuGregory M Marcus
Feb 9, 2017·Cardiovascular Therapeutics·Endalkachew Admassie AlamnehLuke R Bereznicki
Aug 7, 2017·The American Journal of Cardiology·Endalkachew AdmassieLuke R Bereznicki
Jul 18, 2018·Journal of the American College of Cardiology·Sharon W Y LawEsther W Chan
Mar 23, 2019·American Heart Journal·Malini MadhavanUNKNOWN ORBIT AF Investigators
Aug 24, 2019·Journal of the American Heart Association·Adam J RoseHong Yu
Mar 19, 2020·Journal of Clinical Medicine·Woldesellassie M BezabheJan Radford
Jun 7, 2020·BMC Nephrology·Ronald L CastelinoJan Radford
Jul 23, 2020·European Journal of Clinical Investigation·Vincenzo RussoGerardo Nigro
Sep 22, 2020·European Journal of Clinical Investigation·Wern Yew DingTatjana S Potpara

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Citations

May 28, 2021·International Journal of Geriatric Psychiatry·Marco ZuinGiovanni Zuliani

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