Factors influencing parathyroid allotransplantation in rats

The Laryngoscope
M Friedman

Abstract

For nearly a century, researchers have sought to solve the problem of permanent hypocalcemia by allotransplanting the parathyroid glands. A thorough review of the literature revealed conflicting reports, many of which claim success but lack substantial data and sound criteria on which to base the success. At the present, there is no reproducible method of successfully transplanting parathyroid tissue to a nonimmunosuppressed host. The literature on the transplantation of other organs was reviewed in order to determine which methods might be tested on parathyroid tissue to achieve long-term graft survival. These methods include the use of fetal tissue and treatment of the host with cyclosporine. Cyclosporine is unique in that it affects graft rejection but does not alter the nonspecific defenses of the host. Five experimental groups were established to study variables influencing successful allotransplantation. Heterogeneic, parathyroid adult rats with calcium levels below 5.5 mg/dl were the graft recipients. Our criteria for successful parathyroid transplantation included biochemical, functional, and histologic data. Maintenance of serum calcium levels above 8.0 mg/dl was considered biochemical evidence of graft function. Excis...Continue Reading

References

Jul 1, 1976·Agents and Actions·J F BorelH Stähelin
Aug 1, 1976·Transplantation·K J LaffertyD W Talmage
Mar 10, 1979·Lancet·S W JamiesonN E Shumway
Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·R K SpenceC F Barker
Apr 1, 1976·The Journal of Surgical Research·A Naji, C F Barker
Oct 1, 1974·American Journal of Surgery·J H RaafR A Good
Nov 1, 1969·American Journal of Surgery·H MatsuuraF C Marchetta
Oct 1, 1970·American Journal of Surgery·F C MarchettaH Matsuura
May 1, 1966·Archives of Surgery·M A BlockJ M Miller
Oct 6, 1983·The New England Journal of Medicine·UNKNOWN Canadian Multicentre Transplant Study Group
Jan 1, 1981·American Journal of Reproductive Immunology : AJRI·F P Siegal
Mar 1, 1980·Transplantation·K J Lafferty
Sep 1, 1982·Annals of Surgery·B P GriffithH T Bahnson
Apr 1, 1957·Annals of Internal Medicine·R F ESCAMILLAG S GORDAN
Apr 1, 1958·Transplantation Bulletin·J A STERLING
Oct 1, 1958·Transplantation Bulletin·G L JORDANF GYORKEY
May 1, 1959·Plastic and Reconstructive Surgery and the Transplantation Bulletin·H CONWAYJ W SMITH
May 1, 1961·The Journal of Surgical Research·P S RUSSELLR F GITTES
Feb 1, 1963·American Journal of Surgery·S W JACOB, J E DUNPHY
Oct 24, 1962·Annals of the New York Academy of Sciences·R L SIMMONS, P S RUSSELL
Oct 24, 1962·Annals of the New York Academy of Sciences·R Y CALNEJ E MURRAY
Apr 1, 1965·The Surgical Clinics of North America·W T NEWTON
Nov 4, 1961·JAMA : the Journal of the American Medical Association·G L JORDANF GYORKEY
Jan 9, 1909·The Journal of Experimental Medicine·W S Halsted

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Citations

Apr 14, 2005·The Annals of Otology, Rhinology, and Laryngology·Marc NelsonMarshall Strome

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