Sleeping sickness or Human African Trypanosomiasis (HAT) is a neglected tropical disease of public health importance across much of Sub-Saharan Africa. In Uganda, chronic T. b. gambiense HAT (gHAT) and acute T. b. rhodesiense HAT (rHAT) occur in two large but discrete geographical foci. Both forms are difficult to diagnose, expensive to treat and ultimately fatal in the absence of treatment. The area affected by zoonotic rHAT has been steadily expanding, placing a high burden on local health systems. HAT is a disease of neglected populations and is notorious for being under-reported. Here we examine the factors that influence passive rHAT surveillance within the district health system in four Ugandan districts into which the disease had recently been introduced, focusing on staff knowledge, infrastructure and data management. A mixed methods study was undertaken between 2011 and 2013 in Dokolo, Kaberamaido, Soroti and Serere districts to explore health facility capacity and clinical service provision, diagnostic capacity, HAT knowledge and case reporting. Structured interviews were undertaken with 86 medical personnel, including clinicians, nurses, midwives and technicians across 65 HC-II and HC-III medical facilities, where th...Continue Reading
Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene
SOME OBSERVATIONS ON THE RECENT EPIDEMIOLOGY OF SLEEPING SICKNESS IN NYANZA REGION, KENYA, AND ITS RELATION TO THE GENERAL EPIDEMIOLOGY OF GAMBIAN AND RHODESIAN SLEEPING SICKNESS IN AFRICA
Assessing the patterns of health-seeking behaviour and awareness among sleeping-sickness patients in eastern Uganda
Spatial and temporal risk factors for the early detection of Trypanosoma brucei rhodesiense sleeping sickness patients in Tororo and Busia districts, Uganda
Estimating the burden of rhodesiense sleeping sickness during an outbreak in Serere, eastern Uganda.
The treatment pathways followed by cases of human African trypanosomiasis in western Kenya and eastern Uganda
Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden.
Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness) prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda.
Integration of control of neglected tropical diseases into health-care systems: challenges and opportunities
The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases
The human African trypanosomiasis control and surveillance programme of the World Health Organization 2000-2009: the way forward
Health care-seeking behaviour and diagnostic delays for Human African Trypanosomiasis in the Democratic Republic of the Congo
Conflict of interest: use of pyrethroids and amidines against tsetse and ticks in zoonotic sleeping sickness endemic areas of Uganda
Cattle movements and trypanosomes: restocking efforts and the spread of Trypanosoma brucei rhodesiense sleeping sickness in post-conflict Uganda
Incorporating scale dependence in disease burden estimates: the case of human African trypanosomiasis in Uganda
Systematic review on what works, what does not work and why of implementation of mobile health (mHealth) projects in Africa
A mixed methods study of a health worker training intervention to increase syndromic referral for gambiense human African trypanosomiasis in South Sudan
Quantifying the association between bovine and human trypanosomiasis in newly affected sleeping sickness areas of Uganda
The importance of veterinary policy in preventing the emergence and re-emergence of zoonotic disease: examining the case of human african trypanosomiasis in Uganda
Integrated community case management of malaria, pneumonia and diarrhoea across three African countries: A qualitative study exploring lessons learnt and implications for further scale up
Raising the political profile of the neglected zoonotic diseases: three complementary European commission-funded projects to streamline research, build capacity and advocate for control
On the road to elimination of Rhodesiense human African trypanosomiasis: first WHO meeting of stakeholders
Impact of mass chemotherapy in domestic livestock for control of zoonotic T. b. rhodesiense human African trypanosomiasis in Eastern Uganda
Evaluating the impact of targeting livestock for the prevention of human and animal trypanosomiasis, at village level, in districts newly affected with T. b. rhodesiense in Uganda
Estimating the economic and social consequences for patients diagnosed with human African trypanosomiasis in Muchinga, Lusaka and Eastern Provinces of Zambia (2004-2014)
The state of emergency medical services and acute health facility care in Uganda: findings from a National Cross-Sectional Survey
Knowledge, attitudes, and practice of cervical cancer prevention among health workers in rural health centres of Northern Uganda.
Practices in research, surveillance and control of neglected tropical diseases by One Health approaches: A survey targeting scientists from French-speaking countries.
Lived experiences of frontline healthcare providers offering maternal and newborn services amidst the novel corona virus disease 19 pandemic in Uganda: A qualitative study.
African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.