Factors influencing preoperative stress response in coronary artery bypass graft patients

BMC Anesthesiology
Astrid M MorinLeopold Hj Eberhart

Abstract

BACKGROUND: In many studies investigating measures to attenuate the hemodynamic and humoral stress response during induction of anaesthesia, primary attention was paid to the period of endotracheal intubation since it has been shown that even short-lasting sympathetic cardiovascular stimulation may have detrimental effects on patients with coronary artery disease. The aim of this analysis was, however, to identify the influencing factors on high catecholamine levels before induction of anaesthesia. METHODS: Various potential risk factors that could impact the humoral stress response before induction of anaesthesia were recorded in 84 males undergoing coronary aortic bypass surgery, and were entered into a stepwise linear regression analysis. The plasma level of norepinephrine measured immediately after radial artery canulation was chosen as a surrogate marker for the humoral stress response, and it was used as the dependent variable in the regression model. Accordingly, the mean arterial blood pressure, heart rate and the calculated pressure-rate product were taken as parameters of the hemodynamic situation. RESULTS: Stepwise regression analysis revealed that the oral administration of low-dose clonidine (mean dose 1.75 μg.kg-1...Continue Reading

References

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Citations

Jul 11, 2006·Current Opinion in Anaesthesiology·Arthur W Wallace
Jun 7, 2007·Der Anaesthesist·P MeybohmM Bauer
Apr 1, 2012·Anesthesiology and Pain Medicine·Zahra Taghipour AnvariMasood Mohseni

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Methods Mentioned

BETA
sedation
coronary artery bypass

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