Factors influencing relapse during a 2-year follow-up of first-episode psychosis in a specialized early intervention service

Psychological Medicine
Ashok MallaC Cassidy

Abstract

Differential association of risk factors associated with relapse following treatment of first-episode psychosis (FEP) have not been studied adequately, especially for patients treated in specialized early intervention (SEI) services, where some of the usual risk factors may be ameliorated. Consecutive FEP patients treated in an SEI service over a 4-year period were evaluated for relapse during a 2-year follow-up. Relapse was based on ratings on the Scale for Assessment of Positive Symptoms (SAPS) and weekly ratings based on the Life Chart Schedule (LCS). Predictor variables included gender, duration of untreated psychosis (DUP), total duration of untreated illness (DUI), age of onset, pre-morbid adjustment, co-morbid diagnosis of substance abuse during follow-up and adherence to medication. Univariate analyses were followed by logistic regression for rate of relapse and survival analysis with the Cox proportional-hazards regression model for time to relapse as the dependent variables. Of the 189 eligible patients, 145 achieved remission of positive symptoms. A high rate of medication adherence (85%) and relatively low relapse rates (29.7%) were observed over the 2-year follow-up. A higher relapse rate was associated with a co-m...Continue Reading

References

Nov 1, 1976·The Journal of Nervous and Mental Disease·J J Bartko, W T Carpenter
Sep 1, 1992·The American Journal of Psychiatry·A D LoebelS R Szymanski
Mar 1, 1992·Schizophrenia Research·H HäfnerW van der Heiden
Jan 1, 1992·Schizophrenia Bulletin·R RamJ E Schwartz
Jul 1, 1967·Archives of General Psychiatry·R L SpitzerJ Endicott
Jan 1, 1982·Schizophrenia Bulletin·H E Cannon-SpoorR J Wyatt
Apr 1, 1994·Archives of General Psychiatry·D H LinszenM E Lenior
Nov 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·A DavidT Fahy
Jan 1, 1996·Schizophrenia Bulletin·P D McGorryH J Jackson
May 1, 1996·Schizophrenia Research·C D SwoffordL B Inderbitzin
Aug 1, 1996·Psychiatric Services : a Journal of the American Psychiatric Association·R R OwenB J Cuffel
Dec 1, 1996·Biological Psychiatry·M Hambrecht, H Häfner
Feb 7, 2001·Psychiatric Services : a Journal of the American Psychiatric Association·M KamaliE O'Callaghan
Jan 23, 2003·Psychological Medicine·S M HarriganH Krstev
Jan 25, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Hakan JarbinAnne-Liis Von Knorring
May 24, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·F SorbaraH Verdoux
Jul 23, 2003·The Australian and New Zealand Journal of Psychiatry·Ashok MallaLaurel Townsend
Mar 3, 2004·Schizophrenia Bulletin·Matcheri S KeshavanJohn A Sweeney
Mar 3, 2004·The American Journal of Psychiatry·Delbert G RobinsonRobert M Bilder
Mar 17, 2004·Social Psychiatry and Psychiatric Epidemiology·Sarah Van MastrigtDonald Addington
Mar 3, 2005·The American Journal of Psychiatry·Nancy C AndreasenDaniel R Weinberger
Jul 5, 2005·Acta Psychiatrica Scandinavica·M LambertB G Schimmelmann
Jul 12, 2005·Schizophrenia Bulletin·Ashok Malla, Jennifer Payne
Aug 2, 2005·The British Journal of Psychiatry. Supplement·Ross M G NormanMax Marshall
Mar 7, 2006·Psychological Medicine·Ashok MallaRaj Haricharan
Aug 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·L HidesR McD Young
Sep 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·D WadeP D McGorry

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Citations

Nov 7, 2008·Schizophrenia Bulletin·S ArchieR B Zipursky
Sep 12, 2012·Schizophrenia Research and Treatment·Raquel IniestaJudith Usall
Mar 1, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Grant E SaraWayne C Hall
May 28, 2010·International Review of Psychiatry·Brendan P Murphy
Nov 23, 2013·Comprehensive Psychiatry·Elisabeth Heffermehl LangeIngrid Agartz
Jun 23, 2012·Journal of Psychiatric Research·Olalla CaseiroBenedicto Crespo-Facorro
Aug 1, 2009·Early Intervention in Psychiatry·Jason A R CarrRahul Manchanda
Aug 21, 2010·Acta Psychiatrica Scandinavica·Erik SimonsenT H McGlashan
Oct 15, 2009·Acta Psychiatrica Scandinavica·R MazzonciniP Fearon
Nov 15, 2013·Early Intervention in Psychiatry·Jean AddingtonKristin S Cadenhead
Mar 23, 2013·Schizophrenia Research·Albert BatallaMiguel Bernardo
Aug 27, 2013·Schizophrenia Research·Robert B ZipurskyDavid L Streiner
Nov 1, 2016·European Archives of Psychiatry and Clinical Neuroscience·José María Pelayo-TeránRosa Ayesa-Arriola
Feb 5, 2011·Journal of Psychopharmacology·Thomas R E Barnes, UNKNOWN Schizophrenia Consensus Group of British Association for Psychopharmacology
Aug 6, 2019·Acta Psychiatrica Scandinavica·E Setién-SueroR Ayesa-Arriola
Aug 30, 2016·International Clinical Psychopharmacology·Ashok MallaRoss A Baker
Feb 23, 2013·Clinical Schizophrenia & Related Psychoses·Mamta SapraPage Burkholder
Feb 22, 2012·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Emmanuelle LevyAshok Malla
Aug 16, 2013·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Rahul ManchandaNicola Banks
Feb 11, 2020·Frontiers in Psychiatry·Volker BöckmannBenedikt Habermeyer
Sep 25, 2012·Santé mentale au Québec·Clairélaine Ouellet-Plamondon, Amal Abdel-Baki
Feb 24, 2015·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Phil TibboRidha Joober
Feb 16, 2017·Schizophrenia Bulletin·Melissa A WeibellSvein Friis
Dec 1, 2010·Irish Journal of Psychological Medicine·Sami OmerEadbhard O'Callaghan
Oct 12, 2015·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Christy L M HuiEric Y H Chen
Oct 7, 2020·Revista de psiquiatrí́a y salud mental·Miguel BernardoJuan Antonio Micó
Aug 31, 2021·Revista De Psiquiatria Y Salud Mental·Miguel BernardoJuan Antonio Micó

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