Factors influencing the adrenergic neurone blocking action of propranolol

British Journal of Pharmacology
S Eliash, M Weinstock

Abstract

1. The reversal by propranolol of its own adrenergic neurone blocking effect in the cat can be prevented by cutting the splanchnic nerves or by ligating the adrenal veins.2. In the absence of secretion from the adrenal medulla the nerve blocking action of propranolol is more complete, but can still be reversed by repeated injections or a constant infusion of adrenaline.3. Prior treatment with adrenaline or noradrenaline also prevents the development of the blocking action of propranolol in the cat and in the isolated guinea-pig vas deferens.4. It is suggested that in the cat, propranolol stimulates the release of catecholamines from the adrenal medulla which antagonize its nerve blocking effect.

References

Jul 1, 1970·Canadian Journal of Physiology and Pharmacology·D Regoli
Oct 1, 1966·British Journal of Pharmacology and Chemotherapy·S O Kayaalp, B K Kiran
Apr 1, 1961·British Journal of Pharmacology and Chemotherapy·S HUKOVIC
Apr 1, 1962·British Journal of Pharmacology and Chemotherapy·M D DAY
Feb 1, 1963·British Journal of Pharmacology and Chemotherapy·M D DAY, M Rand
Jan 1, 1965·Annual Review of Pharmacology·A L BOURA, A F GREEN

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