Factors influencing the choice of biologic therapy following Rituximab in patients with rheumatoid arthritis: A retrospective study using propensity score.

Joint, Bone, Spine : Revue Du Rhumatisme
Gaëlle VialAnne Tournadre

Abstract

To assess factors influencing the choice and effectiveness of biological disease-modifying antirheumatic drugs (DMARDs) following failure of rituximab (RTX) in rheumatoid arthritis (RA), taking patient profile into account. In a retrospective, multicenter study, data about RA patients starting a new biologic during the year after RTX discontinuation were collected at baseline (when the biologic was introduced after RTX), and during follow-up (3, 6, and 12 months). Characteristics of patients receiving tocilizumab (TCZ), abatacept (ABA), or a TNFα inhibitor (TNFi), EULAR response, and retention rate were compared using multidimensional factorial analysis for patient profiles and multivariate analysis including propensity score built on the patient profile. Among 152 patients analyzed (37.5% TCZ, 31.6% ABA, 30.9% TNFi), sex, disease characteristics and activity, concomitant DMARDs or glucocorticoids, and previous use of RTX and TNFi were similar at baseline. Patients receiving ABA were slightly older. Multimorbidity index was higher but not significantly different. Multidimensional factorial analysis showed a distinct profile of patients receiving ABA, characterized by older age, more men, more smokers, more comorbidities, and hi...Continue Reading

References

Jan 18, 2006·Annals of the Rheumatic Diseases·Z TutuncuA Kavanaugh
Jan 22, 2009·Annals of the Rheumatic Diseases·M C GenoveseT M Shaw
Nov 10, 2009·Journal of Clinical Epidemiology·Nadia SourialHoward Bergman
Aug 19, 2010·Rheumatology·Ulrich A WalkerUNKNOWN Swiss Clinical Quality Management Programme in Rheumatic Diseases
Jul 6, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Cécile Gaujoux-VialaUNKNOWN French Society for Rheumatology
Oct 14, 2018·Joint, Bone, Spine : Revue Du Rhumatisme·Claire DaienBernard Combe
Jan 27, 2019·BMJ : British Medical Journal·Jacques-Eric GottenbergUNKNOWN French Society of Rheumatology and the investigators participating in AIR, ORA, and REGATE registries

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