Factors influencing the development of sigmoid colon cancer. Bacteriologic and biochemical studies

Cancer
K KanazawaH Kimura

Abstract

Cancer of the sigmoid colon is especially sensitive to environmental factors such as food. The authors have conducted a series of studies with food as the external environmental factor and intestinal microflora as the internal environment factor in relation to sigmoid colon carcinogenesis. Thirteen males who had previously undergone surgery for sigmoid colon cancer, and who later developed new epithelial neoplasia of the colon, were chosen as the high risk (HR) group. Fourteen males of similar age, whose large bowel was entirely normal by total colonoscopy, were chosen as the control (CONT) group. Food constituents were analyzed by a dietician. Fecal bile acids, cholesterol metabolites, degradation products of amino acids, pH, water content, and bacterial flora were quantitatively analyzed. Although the HR group consumed slightly more carbon hydrate, fiber, and calcium, as a whole, there was no significant difference in food constituents, especially animal fat, between the two groups. Concentrations of bile acids and cholesterol metabolites were not different between the groups, with the exception of a higher level of cholestanol in the HR group. Succinic, lactic, propionic, and isovaleric acids were abundant in the HR group. F...Continue Reading

References

Sep 20, 1975·Lancet
Nov 1, 1977·Cancer·S A BroitmanL S Gottlieb
Nov 1, 1977·Journal of the National Cancer Institute·S J Silverman, A W Andrews
Aug 1, 1976·Journal of the National Cancer Institute·B R Goldin, S L Gorbach
Nov 1, 1991·Gut·G V AppletonR C Williamson
Jan 16, 1971·Lancet·M J HillR E Williams
Jun 1, 1973·Journal of the National Cancer Institute·B S Reddy, E L Wynder
Jul 1, 1971·Cancer·D P Burkitt
Jan 1, 1971·The American Surgeon·B P Colcock
Mar 1, 1982·Mutation Research·R L Van TassellT D Wilkins

❮ Previous
Next ❯

Citations

Apr 19, 2012·American Journal of Primatology·Hannah V FaceyAndré-Denis G Wright
Feb 3, 2012·Biological Reviews of the Cambridge Philosophical Society·Annemarie Boleij, Harold Tjalsma
Jun 22, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E C ObusezB Shen
May 5, 2004·Best Practice & Research. Clinical Gastroenterology·Patricia M Heavey, Ian R Rowland
Feb 2, 2010·Environmental and Molecular Mutagenesis·Matias S Attene-RamosH Rex Gaskins
Nov 23, 2012·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dae Seong Myung, Young Eun Joo
Feb 25, 2005·FEMS Microbiology Letters·Mairi E HopeEmad M El-Omar
Feb 8, 2016·Trends in Molecular Medicine·Noortje IjssennaggerSaskia W C van Mil
Dec 5, 2013·Carcinogenesis·Scott J Bultman
Aug 2, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N L RitzH C Lin
Sep 2, 1998·Journal of the Royal Society of Health·M F Chaplin
Jun 16, 2011·Inflammatory Bowel Diseases·Mekki MedaniDes C Winter
Jan 24, 2018·Critical Reviews in Microbiology·Cheng-Bei Zhou, Jing-Yuan Fang
Mar 11, 2010·The American Journal of Gastroenterology·Davide RoccarinaAntonio Gasbarrini
May 16, 2012·Nature Reviews. Gastroenterology & Hepatology·Franck CarboneroH Rex Gaskins
May 10, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bart Deplancke, H Rex Gaskins
May 28, 2011·Genes & Nutrition·Jacoline GerritsenWillem M de Vos
Jul 2, 2004·Experimental Biology and Medicine·Mark M Huycke, H Rex Gaskins
Dec 15, 2011·The Journal of Biological Chemistry·Thomas W MillerDavid D Roberts
Apr 3, 2003·Experimental Biology and Medicine·Bart DeplanckeH Rex Gaskins
Mar 18, 2000·The Journal of Nutrition·L J BradyF F Busta
Nov 24, 1999·The American Journal of Physiology·P EvenepoelY Ghoos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
H HorieA Terada
American Journal of Physiology. Gastrointestinal and Liver Physiology
S RamasamyM C Eggo
© 2021 Meta ULC. All rights reserved