Factors influencing the in vitro activity of two new aryl-fluoroquinolone antimicrobial agents, difloxacin (A-56619) and A-56620.

Antimicrobial Agents and Chemotherapy
L Hirschhorn, H C Neu

Abstract

The in vitro activity of difloxacin (A-56619) and A-56620, two new aryl-difluoroquinolones, was decreased by magnesium at 9 mM and in assay at pH 5.5 or in urine. Resistance was seen with members of the family Enterobacteriaceae, Pseudomonas aeruginosa, and Staphylococcus aureus repeatedly exposed to subinhibitory concentrations of the compounds. The frequency of resistance was similar to that found for other new quinolones.

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Citations

Feb 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N X ChinH C Neu
Aug 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N X Chin, H Neu
Jul 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H C Neu, N X Chin
Jun 1, 1987·European Journal of Clinical Microbiology·C Weissauer-CondonF D Daschner
May 1, 1989·Diagnostic Microbiology and Infectious Disease·W W Niu, H C Neu
Jan 1, 1991·International Journal of Antimicrobial Agents·H H Gadebusch, D L Shungu
May 1, 1988·Antimicrobial Agents and Chemotherapy·A M EspinozaH C Neu
Jul 1, 1989·Antimicrobial Agents and Chemotherapy·H C NeuN X Chin
Jul 1, 1989·Antimicrobial Agents and Chemotherapy·H C Neu, N X Chin
Mar 1, 1991·Antimicrobial Agents and Chemotherapy·N X ChinH C Neu
Jun 1, 1992·Antimicrobial Agents and Chemotherapy·H C NeuN X Chin
Nov 1, 1994·Antimicrobial Agents and Chemotherapy·H C Neu, N X Chin
Jul 1, 1988·Medicinal Research Reviews·S W McCombie, A K Ganguly
Oct 22, 2008·Critical Reviews in Biotechnology·C Ganesh KumarAnnapurna Jetty
Oct 1, 1990·Journal of Chemotherapy·P MapleJ M Hamilton-Miller

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