PMID: 1827247Mar 1, 1991Paper

Factors influencing the outcome of congenital heart disease detected prenatally

Archives of Disease in Childhood
G K SharlandL D Allan

Abstract

The diagnosis of structural heart disease before birth is associated with a poor prognosis. Of 222 continuing pregnancies seen in a 10 year period, there has been a 79% mortality. This is inconsistent with published results and current concepts of the outcome for children with cardiac malformation. Of the 222, death occurred in intrauterine life in 57, 87 died as neonates, and 31 in infancy or childhood. There are 47 survivors of whom only five have survived beyond 4 years. Factors influencing the outcome in these cases were examined further. A high mortality was associated with the presence of extracardiac anomalies in 71 (32%) and prenatal cardiac failure in 28 (13%). As many patients were referred for these reasons, referral methods preferentially select patients with a different range of heart disease from that seen postnatally. In addition, some forms of heart disease progress in severity during fetal life. Those involved in the management and counselling after diagnosis of heart disease in early pregnancy must be aware of the additional prenatal factors influencing prognosis and allow for them in making predictions of outcome.

References

Dec 1, 1989·International Journal of Cardiology·L D AllanM J Tynan
Jun 28, 1986·British Medical Journal·L D AllanM J Tynan
Mar 1, 1988·British Heart Journal·M V MachadoL D Allan
Mar 1, 1987·American Journal of Obstetrics and Gynecology·B R Benacerraf, N S Adzick
Nov 1, 1984·British Heart Journal·L D AllanM J Tynan

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Citations

Oct 12, 2012·Pediatric Cardiology·Benjamin J LandisIsmee A Williams
Sep 25, 2012·Annals of Biomedical Engineering·Ryan R HansenKeith B Neeves
Jun 2, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E T JaeggiS G Cooper
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May 25, 2002·Scandinavian Cardiovascular Journal : SCJ·Drude Fugelseth
Jan 1, 1992·American Journal of Obstetrics and Gynecology·G K SharlandL D Allan
Oct 23, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Anita Moon-GradyLisa K Hornberger
Apr 6, 2004·Obstetrics and Gynecology Clinics of North America·Lynn L Simpson
Sep 15, 2005·American Journal of Obstetrics and Gynecology·Fionnuala M McAuliffeLisa K Hornberger
Jun 1, 1992·The American Journal of Cardiology·J F SmytheC S Kleinman
Mar 24, 1998·Prenatal Diagnosis·U Gembruch
Feb 16, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S FechnerM Meyer-Wittkopf
Dec 22, 1999·Annals of Tropical Paediatrics·H Narchi

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