PMID: 9531226Apr 8, 1998Paper

Factors influencing the time to thrombolysis in acute myocardial infarction. Time to Thrombolysis Substudy of the National Registry of Myocardial Infarction-1

Archives of Internal Medicine
C T LambrewW D Weaver

Abstract

The Time to Thrombolysis Substudy of the National Registry for Myocardial Infarction provided the opportunity to identify factors that delay thrombolytic treatment of patients with ST-segment elevation acute myocardial infarction. Forty-two participating registry hospitals volunteered for the Time to Thrombolysis Substudy. A case report form was developed to collect time points for emergency department arrival (door), recording of the electrocardiogram (ECG) (data), entry of the order to give a thrombolytic drug (decision), and initiation of the thrombolytic infusion (drug) as defined by the National Heart Attack Alert Program. The impact of mode of transportation to the hospital, sex, policy-driven cardiology consultation and/or contact of the primary care physician on door-to-drug time, and each component interval were determined in 1755 patients who were treated with recombinant tissue-type plasminogen activator (A1-teplase). The t test was used for comparison of means and the nonparametric sign test was used for medians. A minority of patients arrived at the hospital by ambulance, although more women (49.6%) arrived by ambulance than men (40.9%). However, women arrived at hospitals significantly later after onset of symptom...Continue Reading

Citations

Mar 19, 2004·The Journal of Emergency Medicine·Christopher S WeaverRoland B McGrath
May 15, 2002·The American Journal of Cardiology·Brad G AngejaUNKNOWN Participants in the National Registry of Myocardial Infarction 2-3
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