Factors Influencing the Umbilical Cord Blood Stem Cell Industry: An Evolving Treatment Landscape

Stem Cells Translational Medicine
Carla DesselsMichael Sean Pepper

Abstract

Hematopoietic stem cell transplantation (HSCT) is common practice today for life threatening malignant and non-malignant diseases of the blood and immune systems. Umbilical cord blood (UCB) is rich in hematopoietic stem cells (HSCs) and is an attractive alternative to harvesting HSCs from bone marrow or when mobilized into peripheral blood. One of the most appealing attributes of UCB is that it can be banked for future use and hence provides an off-the-shelf solution for patients in urgent need of a transplantation. This has led to the establishment of publicly funded and private UCB banks, as seen by the rapid growth of the UCB industry in the early part of this century. However, from about 2010, the release of UCB units for treatment purposes plateaued and started to decrease year-on-year from 2013 to 2016. Our interest has been to investigate the factors contributing to these changes. Key drivers influencing the UCB industry include the emergence of haploidentical HSCT and the increasing use of UCB units for regenerative medicine purposes. Further influencing this dynamic is the high cost associated with UCB transplantation, the economic impact of sustaining public bank operations and an active private UCB banking sector. We...Continue Reading

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Citations

Dec 19, 2019·American Journal of Hematology·Takaaki KonumaFumihiko Kimura
May 16, 2019·Bone Marrow Transplantation·Hector MayaniHal E Broxmeyer
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Apr 8, 2021·Bone Marrow Transplantation·Stephanie VairyHenrique Bittencourt
Apr 11, 2021·Cytotherapy·Ignatius M ViljoenMichael S Pepper
Apr 21, 2021·British Journal of Haematology·Sergio QuerolAlejandro Madrigal

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Clinical Trials Mentioned

NCT01193660

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