Factors influencing the use of adaptive radiation therapy in vulvar carcinoma.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology
Fawzi AbuhijlaRamiz Abu-Hijlih

Abstract

We aim to evaluate the variables affecting the frequency of adaptive radiotherapy (ART) in vulvar cancer. ART may be needed throughout a definitive RT course for vulvar carcinoma due to changes in patient's anatomy and tumor response. Charts of patients charts who had been treated with definitive concurrent chemo-radiotherapy for vulvar carcinoma, between January 2015 and December 2019 were inquired. Radiation therapy was delivered using intensity modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT). ART was defined as re-simulation and re-planning based on deformation in the irradiated volume by more than 1 cm. Univariate analysis was conducted to study the impact of patient's demographics as well as tumor characteristics on the frequency of ART. 22 patients were eligible for analysis. Median age at diagnosis was 55 years (range 43-82). Radiotherapy dose was 60-66 Gy over 30-35 fractions (fx). Median primary tumor volume was 30cc (9-140). Median Body Mass Index (BMI) was 32 (range 21-40). Thirteen out of 22 patients (59%) required ART, with median timing at 25 fx (19-31). On univariate analysis, larger primary tumor volume (> = 30cc) was associated significantly with increased frequency of ART (p value = 0...Continue Reading

References

Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Jan 1, 1997·Physics in Medicine and Biology·D YanA Martinez
May 22, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Elisabeth WeissClemens F Hess
Oct 1, 1964·Acta Radiologica: Therapy, Physics, Biology·L R HOLSTI, P J TASKINEN
May 27, 2004·British Journal of Cancer·C McGoughH J N Andreyev
May 25, 2013·AJR. American Journal of Roentgenology·Chitra ViswanathanPriya Bhosale
Jan 1, 2010·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Martyna SrokaWłodzimierz Lobodziec
Jan 21, 2015·Critical Reviews in Oncology/hematology·Rockne HymelCharles B Simone
Mar 30, 2016·International Journal of Radiation Oncology, Biology, Physics·Nitin OhriMadhur Garg
May 1, 2016·International Journal of Radiation Oncology, Biology, Physics·David K GaffneyWalter Bosch
Oct 13, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shalini K VinodLois C Holloway
Jul 22, 2017·International Journal of Cancer. Journal International Du Cancer·Yoon-Jung KangKaren Canfell
Jul 26, 2017·Advances in Radiation Oncology·Yuan James RaoPerry W Grigsby
Feb 2, 2018·Cancer Management and Research·Swarupa MitraSoumya Dutta
Apr 28, 2019·Seminars in Radiation Oncology·Jan-Jakob SonkeCoen Rasch

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