PMID: 7992360Dec 15, 1994Paper

Factors influencing vertebral bone density after renal transplantation

T WolpawD E Hricik


In an effort to determine the influence of immunosuppressive therapy and other clinical variables on posttransplant osteopenia, vertebral bone density was measured at least 6 months after transplantation in 65 adult primary renal transplant recipients receiving a variety of immunosuppressive regimens. Fifteen of the 65 patients (23%) had vertebral bone densities below a fracture threshold of 1.0 g hydroxyapatite/cm2. Multivariate analyses indicated that cumulative steroid dose and female gender were the major independent predictors of low vertebral bone density. In women, postmenopausal status also was associated with osteopenia. There was no correlation between cumulative cyclosporine dose and bone density. Results of this study indicate that posttransplant osteopenia is common in renal transplant recipients, including those treated with CsA. Although CsA has allowed the use of lower cumulative doses of steroids, concomitant steroid therapy remains the preeminent factor accounting for loss of bone density.


Jul 7, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Vincent M BrandenburgJürgen Floege
May 17, 2000·Transplantation Proceedings·A UğurR Erdal
Mar 27, 2001·Transplantation Proceedings·D KovacA F Bren
May 16, 2002·Transplantation Proceedings·Ewa Nowacka-CieciuraW Rowinski
Jun 24, 1998·Transplantation Proceedings·D E Hricik
Sep 2, 1998·Transplantation Proceedings·D E Hricik, J A Schulak
Dec 5, 1998·Transplantation Proceedings·H KimS Park
Jan 20, 2004·Seminars in Nephrology·Stuart M Sprague, Michelle A Josephson
Jan 4, 2013·Kidney International·Lucas E NikkelUNKNOWN CURE Group (The Columbia University Renal Epidemiology Group)
Nov 14, 1997·Kidney International·P U Massari
May 7, 1999·Kidney International·A M Cueto-ManzanoR Gokal
May 20, 2003·Kidney International. Supplement·Coral MontalbanManuel Arias
Sep 14, 2010·Transplantation Proceedings·M M SikgencU Erken
Sep 17, 2013·Clinical Transplantation·Athanasios ChristoforidisFotios Papachristou
Jul 30, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Arthur J Matas
Aug 15, 2002·Transplantation·Eileen A O'ShaughnessyBertram L Kasiske
Sep 28, 2002·Transplantation·Stéphanie DurieuxCorinne Isnard Bagnis
Mar 11, 2017·Reviews in Endocrine & Metabolic Disorders·Gerardo SarnoParide De Rosa

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