Factors involved in initiation and regulation of complement lectin pathway influence postoperative outcome after pediatric cardiac surgery involving cardiopulmonary bypass

Scientific Reports
Mateusz MichalskiMaciej Cedzynski

Abstract

Congenital heart disease (CHD) often requires surgical intervention, and is sometimes associated with life-threatening post-operative complications. We have investigated some factors of the innate immune system involved in the initiation or regulation of complement lectin pathway activation (MASP-1, MASP-2 MASP-3, MAp19, MAp44, ficolin-3) and related them to complications and prognosis in 190 pediatric patients undergoing CHD repair with the use of cardiopulmonary bypass (CPB). Patients with MAp44 levels ≤1.81 µg/ml more frequently experienced low cardiac output syndrome (LCOS), renal insufficiency, systemic inflammatory response syndrome (SIRS) and multiorgan dysfunction (MODS). Low MASP-3 (≤5.18 µg/ml) and high MASP-1 (≥11.7 µg/ml) levels were often associated with fatal outcome. Low ficolin-3 concentrations (≤10.1 µg/ml) were more common among patients experiencing SIRS and MODS than in those without complications. However, patients suffering from SIRS and MODS with low ficolin-3 had a much better prognosis (91% survival vs. 37% among other patients; p = 0.007). A discriminating value of 12.7 µg/ml ficolin-3 yielded 8% vs. 60% mortality (p = 0.001). Our data extend the knowledge concerning involvement of proteins of the lect...Continue Reading

References

Aug 31, 2001·The Journal of Biological Chemistry·V RossiG J Arlaud
Oct 25, 2002·Immunobiology·Krishnan HajelaRobert B Sim
Jul 31, 2004·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Francois Lacour-GayetUNKNOWN Aristotle Committee
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brahm GoldsteinUNKNOWN International Consensus Conference on Pediatric Sepsis
Oct 6, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Quanhe YangMargaret A Honein
Oct 2, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael G GaiesJennifer C Hirsch
Nov 18, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Søren E DegnSteffen Thiel
Apr 24, 2010·Arquivos brasileiros de cardiologia·Leonardo Cavadas da Costa SoaresNelson Itiro Miyague
Aug 30, 2011·Journal of Immunological Methods·Søren E DegnJens C Jensenius
Jan 10, 2012·Immunobiology·Mateusz MichalskiMaciej Cedzynski
Jul 17, 2012·Anesthesia and Analgesia·Gregory L StahlJerrold H Levy
Apr 19, 2013·PloS One·Zoltán ProhászkaPeter Garred
Jun 8, 2013·Cancer Immunology, Immunotherapy : CII·Agnieszka SzalaMaciej Cedzynski
Jun 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Søren E DegnSteffen Thiel
Aug 6, 2013·Molecular Immunology·Troels R KjaerGregers R Andersen
Nov 13, 2013·Cardiovascular Journal of Africa·Julien Ie Hoffman
Feb 25, 2014·European Heart Journal. Acute Cardiovascular Care·Charlotte B HoltTroels K Hansen
Feb 26, 2014·The Annals of Thoracic Surgery·Chao XuanGuo-Wei He
Sep 3, 2014·Immunobiology·Mateusz MichalskiMaciej Cedzynski
Nov 11, 2014·Journal of Cardiac Surgery·Murat GüvenerOrhan Saim Demirtürk
Jan 13, 2015·Journal of the American College of Cardiology·Giampaolo GrecoTimothy J Gardner
Dec 3, 2015·Journal of Neuroinflammation·Jian-Wei PanRen-Ya Zhan
Dec 8, 2016·Clinical and Experimental Immunology·A TroldborgS Thiel
Mar 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon A MortensenSøren E Degn
Jun 1, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Łukasz EppaMaciej Cedzyński
Aug 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rasmus PihlSteffen Thiel

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Citations

Aug 6, 2020·International Journal of Molecular Sciences·Gabriela GajekMaciej Cedzyński
Jul 1, 2020·Scientific Reports·Anna SokołowskaMaciej Cedzyński
Jan 18, 2021·Basic & Clinical Pharmacology & Toxicology·Jiyang XuHong Zhang

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