Factors of the insulin resistance syndrome in nondiabetic and diabetic elderly Japanese-American men

American Journal of Epidemiology
K L EdwardsM A Austin

Abstract

Factor analysis has previously identified four independent factors that characterize the insulin resistance syndrome in women, interpreted as 1) weight/waist, 2) lipids, 3) insulin/glucose, and 4) systolic and diastolic blood pressure. Because it is not known whether similar factors emerge for men, or for diabetics, factor analysis was used to investigate the clustering of features characterizing the insulin resistance syndrome using data from 3,159 elderly (71-93 years) Japanese-American men participating in the fourth examination of the Honolulu Heart Program during 1991-1993. Consistent with previous results, factor analysis reduced eight risk factors (insulin, glucose, systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, weight, and waist circumference) to four uncorrelated factors that explained 78.2% and 74.7% of the variance in nondiabetics (n = 2,760) and diabetics (n = 399), respectively. These factors were interpreted as 1) weight/waist, 2) blood pressure, 3) lipids, and 4) insulin/glucose. Modest differences in the associations between fasting insulin and factors 1, 3, and 4 were noted for diabetics. These consistently identified composite factors may represent marke...Continue Reading

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Citations

Sep 24, 2004·Diabetes/metabolism Research and Reviews·Arnab Ghosh
Oct 12, 2000·Diabetes Research and Clinical Practice·W Y FujimotoP W Wahl
Dec 15, 2005·Heart, Lung & Circulation·Paul Nestel
Aug 13, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·E MannucciC M Rotella
May 29, 2004·Current Opinion in Lipidology·Paul Nestel
Jun 8, 2000·Annals of the New York Academy of Sciences·P ZimmetM de Courten
Jun 8, 2000·Annals of the New York Academy of Sciences·M E Patti
Jan 14, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masazumi AkahoshiKatsusuke Yano
Nov 30, 2006·Archives of Physiology and Biochemistry·Constantin Ionescu-TirgovisteEduard Apetrei
Oct 20, 2009·Journal of Psychosomatic Research·Masayo KojimaShinkan Tokudome
May 23, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giuseppe PennoStefano Del Prato
Jan 21, 2014·Journal of Psychosomatic Research·Tomoko UdoCarlos M Grilo
Jul 28, 2004·Diabetes Care·Jee-Young OhElizabeth Barrett-Connor
Sep 28, 2002·Diabetes·Robert L HansonWilliam C Knowler
Jul 30, 2002·Diabetes·Anthony J G HanleyUNKNOWN Insulin Resistance Atherosclerosis Study
Nov 25, 2003·Diabetes Care·Anthony J G HanleyBernard Zinman
Jun 30, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Claudio L LafortunaAlessandro Sartorio
Oct 31, 2006·American Journal of Hypertension·Ming-Wei LinUNKNOWN SAPPHIRe Study Group
Aug 4, 2005·The Annals of Pharmacotherapy·Julienne K KirkK M Venkat Narayan
Dec 26, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Sarah D De Ferranti, Stavroula K Osganian
Aug 15, 2002·International Journal of Epidemiology·Veli-Pekka ValkonenJukka T Salonen
Aug 31, 2002·American Journal of Human Biology : the Official Journal of the Human Biology Council·T Kue YoungMin Zhang

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