PMID: 6984327Jan 1, 1982Paper

Factors of tonsillar involution: age-dependent changes in B-cell activation and Langerhans' cell density

Archives of Oto-rhino-laryngology
G SiegelS Macheleidt

Abstract

Incorporation of radioactive thymidine as well as morphological and autoradiographical investigations performed with isolated B and T lymphocytes of the tonsil show that first of all B cells are activated or proliferating. The combination of autoradiography with cytochemistry was the only means of detecting a few activated T cells. With increasing age the number of activated B cells decreases. A reduced number of Langerhans' cells acting as antigen receptors in the epithelium of the crypt is assumed to be one cause of this phenomenon. Tonsillar involution originates from both a decline in the antigen receptors and in the depletion of B-cell activation. Malfunctions in these processes give rises to pathogenic factors in chronic tonsillitis.

References

Jan 1, 1979·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·G Siegel
Jan 1, 1976·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·G Siegel, J Wilke
Mar 1, 1980·Acta Oto-laryngologica·L Surján

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Citations

Nov 7, 2012·Expert Opinion on Investigational Drugs·Leila Kheirandish-GozalDavid Gozal

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